Mebendazole is white, white-like or yellowish crystalline powder. Soluble in formic acid, slightly soluble in glacial acetic acid and bitter almond oil, slightly soluble in acetone or chloroform, insoluble in water. Non-hygroscopic and stable in air. Pure mebendazole powder is a benzimidazole derivative. It is a broad-spectrum drug for expelling intestinal worms, and it is effective against intestinal worms such as roundworm, hookworm, pinworm, whipworm, tapeworm and strongyloides faecalis.
| Molecular formula |
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Test items |
Specifications |
Results |
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Characteristic |
A white or almost white powder |
Almost white powder |
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Solubility |
Practically insoluble in water,in alcohol and in methylene chloride,It shows polymorphism |
conforms |
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Infrared Absorption |
Comform to the spectrum obtained from Mebendazole RS. |
conforms |
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Related substances |
Impurity G not more than 0.5% Any other individual impurity not more than 0.25% Total impurities not more than 1.0% |
<0.05% <0.05% <0.05% |
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Loss on drying |
Not more than 0.5% |
0.06% |
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Residue on ignition |
Not more than 0.1% |
0.06% |
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Partical size distribution |
Particals smaller than 20um should be no less than 90% |
conforms |
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Assay |
It contains not less than 99.0% and not more than 101.0% of C16H13N3O3 calculated on the dried basis |
99.8% |
| Conclusion： |
Conform with enterprise specification . |
What is the mechanism of action of this product?
Mebendazole powder belongs to the class of benzimidazole amino acid ester drugs, which are suitable for expelling intestinal parasitic infections and have significant effects on killing larvae and inhibiting the development of insect eggs. We know that glucose in insects is generally transported passively and actively diffused from the intestinal lumen fluid of the insect through the single-cell layer intestinal wall to the prosthetic lumen fluid. The effect of mebendazole active molecule on the parasite is based on this. Researchers believe that high-quality mebendazole can selectively and irreversibly interfere with glucose transport, thereby inhibiting the uptake of glucose by insects. Both in vivo and in vitro experiments have shown that it can directly inhibit the uptake of glucose by nematodes, leading to glycogen depletion and reducing the formation of adenosine triphosphate in the parasite, making it unable to survive. In addition, in the field of ultrastructure, microtubule degeneration occurs in the cytoplasm of the parasite membrane cells and intestinal cells, causing the aggregation of Golgi endocrine granules, resulting in transport blockage, cytoplasmic dissolution and absorption, complete cell degeneration, and other obstacles to the formation of the parasite cell microtubule system, causing the cell cycle to stagnate in the G2/M phase, affecting cell mitosis, and thus affecting the birth of new parasite cells.
What are the benefits and effects of this product?
Hot sales Mebendazole is a derivative of benzimidazole, which can affect various biochemical metabolic pathways of parasitic organisms and bind with β - tubulin to inhibit microtubule aggregation, thereby suppressing secretion granule transport and other subcellular movements. Therefore, it is a broad-spectrum anthelmintic, clinically effective against intestinal worms such as roundworms, hookworms, pinworms, whipworms, tapeworms, and fecal roundworms, but ineffective against echinococcosis. In addition, it is not only highly effective against various gastrointestinal nematodes in animals, but also has good effects on certain tapeworms, and is one of the few good medicines for treating trichiasis.
This product has a much higher affinity for the β - tubulin of parasites than mammals, which is the reason for its selective toxicity to the parasite.
According to the latest report, MBZ powder has a very good inhibitory effect on the proliferation of CCRF-CEM and drug-resistant strain CEM/C1 in acute T lymphoblastic leukemia cells, and the inhibitory effect of MBZ on the proliferation activity of acute T lymphoblastic leukemia cells becomes more significant with the increase of MBZ concentration and the prolongation of medication time.
Mebendazole raw powder is also an oxidative phosphorylation uncoupling agent that can inhibit mitochondrial malate reductase, reduce glucose transport, and thus affect ATP production. It is the development direction of future weight management products, but due to its strong toxic reactions, it is still in the hypothetical stage.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide mebendazole powder etc. at a more favorable price. If you are interested, please leave a message.
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