Vancomycin Powder CAS 1404-90-6

What is Vancomycin powder used for?

1 treatment of serious infections caused by susceptible organisms resistant to penicillins, such as methicillin-resistant S. aureus (MRSA) and multidrug-resistant S. epidermidis (MRSE), 2 treatment of infections in individuals with serious allergy to penicillins, 3 treatment of pseudomembranous colitis caused by C. difficile; in particular, in cases of relapse or where the infection is unresponsive to metronidazole treatment (for this indication, vancomycin is given orally rather than intravenously), 4 treatment of infections caused by Gram-positive microorganisms in patients with serious allergies to beta-lactam antimicrobials, 5 antibacterial prophylaxis for endocarditis after certain procedures in penicillin-hypersensitive people at high risk, 6 surgical prophylaxis for major procedures involving implantation of prostheses in institutions with a high rate of MRSA or MRSE,

7 early in treatment as an empiric antibiotic for possible MRSA infection while waiting for culture identification of the infecting organism,

8 halting the progression of primary sclerosing cholangitis and preventing symptoms; vancomycin does not cure the patient and success is limited,

9 treatment of endophthalmitis by intravitreal injection for Gram-positive bacteria coverage;it has been used to prevent the condition but is not recommended due to the risk of side effects. If you need it, pls click e-mailsales1@faithfulbio.com

what is the Mechanism of action of Vancomycin powder?

Vancomycin powder inhibits bacterial cell wall synthesis by binding to the D-Ala-D-Ala peptide motif of the peptidoglycan precursor, thereby preventing its processing by the transglycosylase; as such, vancomycin disrupts the transglycosylation activity of the cell wall synthesis process. The disruption leads to an incomplete and corrupted cell wall, which makes the replicating bacteria vulnerable to external forces such as osmotic pressure, so that the bacteria cannot survive and are eliminated by the immune system.

Mechanism of vancomycin action and resistance: This diagram shows only one of two ways vancomycin acts against bacteria (inhibition of cell wall cross-linking) and only one of many ways that bacteria can become resistant to it. Vancomycin is added to the bacterial environment while it is trying to synthesize new cell wall. Here, the cell wall strands have been synthesized, but not yet cross-linked. Vancomycin powder recognizes and binds to the two D-ala residues on the end of the peptide chains. However, in resistant bacteria, the last D-ala residue has been replaced by a D-lactate, so vancomycin cannot bind.

In the resistant bacteria, cross-links are successfully formed; still, in the nonresistant (sensitive) bacteria, the vancomycin bound to the peptide chains prevents them from interacting properly with the cell wall cross-linking enzyme.

In the resistant bacteria, stable cross-links are formed. In the sensitive bacteria, cross-links cannot be formed and the cell wall falls apart.

Product Specification

Conclusion：Conform with specification and qualified.