Palmatin CAS 3486-67-7

Palmatine is an alkaloid extracted from herba fibraureae recisae, also known as Palmatine chloride hydrate. The main components are tetrandrine, berberine, etc. Palmatine hydrochloride has a wide range of pharmacological and biological activities, and is mainly used to treat bacillary dysentery caused by gastrointestinal bacterial infection. In addition, because of its excellent antibacterial effect, it is also widely used in respiratory tract infection, urinary system, surgical infection, gynecological inflammation and so on. Therefore, Palmatin powder is called "plant antibiotic" in contemporary medicine. However, due to people's intensive collection, the demand exceeds the supply, and now it has to be cultivated artificially. At present, Guangxi, China has the largest planting base of Huangteng in the world.

Why is palmatin powder called natural antibiotic?

Fibrauretine powder is a hydrochloride alkaloid extracted from herba fibraureae recisae, also known as palmatine hydrochloride. Palmatin is known as "plant antibiotic" by the industry image because of its broad antibacterial spectrum, small toxic and side effects, good effect and difficult drug resistance. fibrauretin is a pure natural plant medicine independently researched and developed in China. At present, the composition of palmatine powder is mainly obtained in two forms: one is natural extraction; The second is artificial synthesis. After a large number of experimental data feedback, there is no obvious difference between the two, and both can play a practical role in clinical use.

What are the benefits of Palmatin for the body?

The main chemical components in the plant herba fibraureae recisae are alkaloids, in which the content of Bamatin is as high as 3%, so the high-quality Rotundine 10097-84-4 can be prepared from herba fibraureae recisae. According to related research, Huangteng alkaloids has different degrees of bacteriostatic effect on 12 kinds of fungi such as Klebsiella epidermidis.

In animal experiments, It can increase the phagocytic rate of neutrophils in peripheral blood of rats, the positive percentage of acid α - naphthyl acetate esterase, the percentage of splenic rose forming cells, promote leukocyte migration inhibition test, and reduce migration inhibition index. This indicates that this product can enhance cellular immunity, humoral immunity, and non-specific immune function with resveratrol. After long-term observation, It also has the following functions:

1. Antimicrobial activity

The research method using microdilution showed that the chloroform and methanol extracts of herba fibraureae recisae from the root bark, pulp, and vine stem have similar antibacterial activity, with inhibition zones of 10-20 mm. The average minimum inhibitory concentration (MIC) value is 80-640 mg/L, indicating that the chemical components contained in Huangteng have good anti deep fungal activity and can be used as candidate products for antifungal drugs. In addition, according to relevant studies, palmatine hcl powder has a better antibacterial effect on Staphylococcus aureus than BERBERINE CHLORIDE 141433-60-5, NUCIFERINE 475-83-2, and ISOTETRANDRINE 477-57-6.

2. Anti-inflammatory effect

Research has found that both synthetic and natural products can increase the carbon clearance index of normal mice, with no significant difference in the carbon clearance index of mice. This indicates that both can enhance non-specific immunity in mice and have significant anti-inflammatory and immune functions. Through in vitro testing, it was found that Palmatine Hydrochloride has an in vitro anti Trichomonas vaginalis effect, and the changes in inhibition rate at different times show a good linear correlation with drug concentration. Compared with metronidazole, which has known therapeutic effects, its activity in inhibiting Trichomonas vaginalis is comparable to metronidazole, indicating that Palmatine powder is an ideal candidate drug for treating Trichomonas vaginalis and has broad prospects for development and utilization.

3. Enhance immunity
Studies have shown that the long-term use of fibrauretine can enhance the phagocytosis of leukocytes, increase the phagocytosis rate of neutrophils in peripheral blood of rats, the percentage of rose-forming cells in spleen and the positive percentage of acidic α -naphthylacetate esterase, and promote the leukocyte migration inhibition test. This shows that fibrauretine can improve the nonspecific immunity, cellular immunity and humoral immunity of rats.

4. Other research progress

Palmatin is an isoquinoline alkaloid. Besides the above functions, this product also has many pharmacological effects such as anti-diabetes and anti-oxidation. When we give a certain amount of haungtengsu to diabetic rats with cognitive impairment, after about 6 weeks, we find that this product can effectively improve the cognitive impairment of diabetic rats and improve their cognitive ability. In addition, high-purity fibrauretine can inhibit the activity of NS2B-NS3 protein of West Nile virus, and also inhibit yellow fever virus and dengue virus in a dose-dependent manner, which provides a comprehensive theoretical basis for the application of palmatin powder in the diagnosis and treatment of yellow fever virus infection. The jatrorrhizine extracted from Huangteng has certain activity of killing plasmodium, especially for Plasmodium falciparum. Studies have shown that fibrauretine can relax the arterial smooth muscle of mice in a concentration-dependent manner, and in-depth studies have shown that the relaxation is related to the decrease of cytosolic Ca2+. In addition, we also found that different concentrations of ethanol extract of Rattan can inhibit the proliferation of human hypertrophic scar fibroblasts and change the morphology of fibroblasts in a dose-dependent manner, and there is no obvious cytotoxicity when the mass concentration is below 300 mg/L.

What is the development prospect of fibrauretin plant antibiotics?

Huangteng su has a wide range of pharmacological and biological activities. However, due to extensive collection and high demand, natural Chinese medicine Huangteng raw materials are becoming increasingly scarce. Research on its chemical composition is stagnant, and pharmacological effects focus on Huangteng su's anti-inflammatory and antibacterial properties. Although Huangteng su has been proven to have good pharmacological activity, there is still a lack of in-depth research on its mechanism of action. Nevertheless, this product has made the following progress:
1.At present, the process of extracting high-purity Palmatin powder from the plant luteolin has gradually matured, and China's artificial cultivation technology in Plant herba fibraureae recisae has also become increasingly mature. This provides a material basis for the development of combination drugs and new dosage forms, as well as the continuous development of pharmacological research.
2. Huangteng extract has antibacterial or bacteriostatic effects, and is characterized by a wide spectrum of antibacterial activity, minimal toxic side effects, good efficacy, and low susceptibility to drug resistance. Especially for some bacterial strains that have developed resistance to antibiotics or mutated strains, berberine still has a good inhibitory effect on them. This will increase the clinical application value of Huangtengsu preparations.

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