Berberine Chloride Powder CAS 141433-60-5

Because berberine chloride powder can mainly be extracted from plants such as Huanglian and Huangbai needles. So, berberine hydrochloride, also known as berberine, can fight against pathogenic microorganisms, especially Shigella, which has the strongest effect. Therefore, it is often used in clinical practice to treat gastrointestinal diseases such as bacterial gastroenteritis and dysentery.

Take berberine hydrochloride before or after meals?

There is no relevant regulation on the time of using berberine hydrochloride in clinic, but because the conventional use of this product is to treat digestive tract infections such as acute gastroenteritis and colitis, it can effectively relieve patients' bad digestive tract symptoms such as diarrhea, abdominal pain and vomiting. Therefore, we suggest using it after meals according to the abnormal stomach of users. Because this product has fewer side effects, it doesn't matter even if it is used once in a while before meals. However, this product is a popular product, just like montelukast sodium and aspirin. In other words, people often carry a simple drug for prevention and treatment when traveling or on business trips. It should be noted that Berberine chloride hydrate 97% is mainly suitable for infectious diarrhea, that is, there is a bad situation caused by bacterial infection in the gastrointestinal tract. It has no effect on non-infectious diarrhea.
Therefore, don't eat a few berberine tablets in advance when you go out to eat in order to avoid diarrhea. This is inappropriate, which will not only accumulate the side effects of coptis chinensis, but also delay the cause.

What are the effects of berberine hydrochloride tablets?

berberine chloride tablets belong to a compound preparation. The main components in the preparation are berberine hydrochloride and auxiliary materials (mainly including polysorbate, colloidal silica, sodium carboxymethyl starch, starch, etc.), and the main components are made from the extract of Chinese medicine Coptidis Rhizoma, which has a good effect of inhibiting germs. Relevant scientific experiments show that it can inhibit the activity of Shigella, Mycobacterium tuberculosis, Streptococcus pneumoniae, Escherichia coli, meningococcus, Vibrio cholerae, Salmonella typhi and other bacteria to a certain extent, so as to kill the bacteria and have an immediate effect on intestinal infection. And this drug has bacteriostatic effect when the concentration is relatively low, and it will have bactericidal effect when the concentration is relatively high. It is also used as an auxiliary drug for arrhythmia in clinic, because it can block α receptor, so it is mainly used in some cases of atrial premature beats or ventricular premature beats, but it is disappointing to rely entirely on berberine to treat arrhythmia. Because there are many causes of arrhythmia, it is necessary to determine whether it is caused by coronary heart disease or myocarditis. Some arrhythmias are self-healing, and you don't have to do anything. As long as your emotional excitement is not exciting, or after the stress is relieved, or after staying up late and having a good rest, it can heal itself. Some of them are caused by other reasons, for example, you have hyperthyroidism, and when you cure hyperthyroidism, your arrhythmia will be fine.

How to understand the problem that berberine hydrochloride can lower blood sugar?

The berberine chloride is not specifically used to treat diabetes. Although it has a certain hypoglycemic effect, there is no data support for the efficacy of diabetes. If you find that the blood sugar rises significantly, it is recommended that you first determine which type of diabetes it is, and then choose to use targeted hypoglycemic products for treatment.
The reason why berberine hydrochloride tablets lower blood sugar is speculated to be through inhibiting oxidative stress, improving mitochondrial metabolism, or improving insulin sensitivity to lower blood sugar. However, clinical trials have been conducted and it has been found that the hypoglycemic effect of berberine hydrochloride tablets is not stable, and the degree of blood glucose reduction cannot be observed in all patients. In many current studies, we combine berberine and metformin. In contrast, it is found that berberine can reduce fasting blood glucose in patients with type 2 diabetes, but its efficacy is not higher than metformin. The effect of berberine on postprandial blood glucose, glycosylated hemoglobin, BMI index, and blood lipids is not precise. Therefore, berberine can be used as an auxiliary means to lower blood glucose and made into a specific hypoglycemic food supplement, but it cannot replace traditional hypoglycemic products.Our company strongly supports your further research and development of berberine. If you are interested, please leave us a message via email：sales6@faithfulbio.com

Other small knowledge about this product

Berberine is a quaternary ammonium alkaloid, and yellow needle-like crystals can be precipitated from ether. Melting point 145°C;; It can be slowly dissolved in cold water (1∶20) or cold ethanol (1∶100), but relatively soluble in hot water or hot ethanol, but hardly soluble in benzene, ether and chloroform. The solubility of its salts in water is relatively small, such as 1: 500 for hydrochloride and 1:30 for sulfate. The traditional extraction methods of berberine mainly include acid water extraction, alkaline water extraction and ethanol extraction. In addition to being a plant antibiotic for treating intestinal infection, it is also used for fluorescent staining of heparin sodium in mast cells in the medical field.
At present, we are studying the effect of this product on improving hyperlipidemia. And regulating the expression of Pgp gene in hepatocellular carcinoma cells.

How to understand its excellent antibacterial ability?

Based on the previous context, we understand that berberine has broad-spectrum antibacterial activity and strong antibacterial activity against Staphylococcus epidermidis, Neisseria meningitidis, and Escherichia coli. It has unique therapeutic effects on cholera, Giardia, Shigella, and Salmonella.
But we don't know what the principle behind this is. After several years of hard research, researchers have finally discovered that berberine can compete with the coenzyme pyridoxal phosphate in bacteria for tyrosine decarboxylase, and it also competes with the enzyme protein on tryptophan enzyme, thereby producing irreversible antibacterial effects; Inhibiting the oxidation of pyruvic acid during bacterial glucose metabolism limits the utilization of vitamin AT and nicotinamide by bacteria, thereby achieving antibacterial effects; Inhibit the synthesis of NDA, RNA, proteins, and lipids in bacteria, thereby interfering with bacterial reproduction

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, so we can not only provide customers with the required berberine chloride powder products,Also support the research, production and sales of other Raw materials of Chinese herbal ingredients.

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