Glycyrrhizic Acid Powder CAS 1405-86-3

Glycyrrhizic acid, also known as glycyrrhizin, is a glycoside composed of glycyrrhetinic acid and 2 molecules of glucuronic acid. High-quality Glycyrrhizic acid powder is white to yellowish crystal, odorless, with special sweetness, which is about 200 times as sweet as sucrose. Moreover, in taste, the sweetness of this product is different from that of sweeteners such as sucrose. It takes a while to get a sweet feeling after eating, but it lasts for a long time. A small amount of liquiritin combined with sucrose can use 20% less sucrose while keeping the sweetness unchanged. Although it has no fragrance, it has the effect of enhancing fragrance. The aqueous solution is weakly acidic, and the pH value of 2% solution is 2.5~3.5. Insoluble in water and dilute ethanol. Soluble in hot water, it is viscous jelly after cooling. The raw materials for processing GLYCYRRHETINIC ACID GLYCOSIDE in the factory come from the roots and rhizomes of Glycyrrhiza uralensis Fisch, a leguminous plant, which is rich in GLYCYRRHYCIC ACID active ingredients, accounting for about 10%.

What are the main application fields of Glycyrrhizic Acid Powder?

The application ratio of glycyrrhizic acid powder in various industries is as follows: 26% for medicine and cosmetics, 70% for food, and 4% for cigarettes and others.
In food: 1. Soy sauce: Glycyrrhizic acid can not only improve the salty taste to improve the inherent taste of soy sauce, but also eliminate the bitter taste of saccharin, which has synergistic effect on chemical flavoring agents. 2. Pickles: In the bittern method of pickling pickles with saccharin, the bitterness of saccharin can be eliminated. In the curing process, it can overcome the shortcomings such as fermentation failure, discoloration and hardening caused by adding less sugar. 3. Seasoning: This product can be added with pickling seasoning liquid, seasoning powder or temporary seasoning when eating, which can increase the sweetness and reduce the strange smell of other chemical seasonings. 4. Bean sauce: Pickled herring with small sauce can increase sweetness and make the taste even.

In medicine and cosmetics: 1. Glycyrrhizic acid is a natural surfactant, and its aqueous solution has weak foaming property. 2. It has AGTH-like biological activity, strong antibacterial and anti-inflammatory functions, and is often used to treat mucosal diseases. It can prevent dental caries and mouth ulcers when used in oral hygiene products. 3. It has wide compatibility, and its use in skin care products can enhance the efficacy of other active substances in sun protection, whitening, itching relieving, conditioning and scar healing. 4. Compounded with Aescin and Aescin, used as an effective antiperspirant.

What is the anti-inflammatory and anti-viral principle of Glycyrrhizic acid powder?

Glycyrrhizic acid is a triterpenoid compound with natural biological activity in the roots and stems of Glycyrrhiza uralensis Fisch. It is the main component of Glycyrrhiza uralensis Fisch. This substance has been used to treat chronic hepatitis and other inflammations in clinic. According to clinical research data, glycyrrhizic acid powder can obviously inhibit HIV replication in blood mononuclear cells of HIV-positive patients in vitro. Glycyrrhizic acid can also reduce the morbidity and mortality of mice infected with lethal dose of influenza virus. Glycyrrhizic acid has the strongest inhibition on the replication of two SARS coronaviruses FFM-1 and FFM-2. Although a large number of sources or news have reported the anti-inflammatory effect of glycyrrhizic acid, so far, its mechanism has not been fully clarified. However, with the development of research, scientists have increasingly recognized that glycyrrhizic acid powder plays an anti-inflammatory role by regulating the expression of HMGB1, NF-κB, cyclooxygenase-2 (COX-2), ILS and TNF, reducing the damage and apoptosis of cells due to oxidative stress, and improving the level of inflammatory factors in cells.

What are the studies on glycyrrhizic acid derivatives?

When glycine ethyl ester hydrochloride is introduced into the glycoligand of glycyrrhizic acid, its structure is shown in the right figure, and its thrombin and hemolysin are increased by nearly 3 times and 2 times, respectively, while the 30th carboxyl group is kept bare. After valine tert-butyl is introduced into the glycoside, its hemolysin level is increased by 50% compared with the protection of the 30th carboxyl group. After amino acids and short peptides are introduced into the glycoligand of glycyrrhizic acid, its anti-SARS effect is about 10 times higher than that of glycyrrhizic acid, especially when glycine and lysine short peptides are introduced into the glycoside bond, its anti-SARS effect is about 10 times higher than that of glycyrrhizic acid powder.

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