Ergothioneine Powder CAS 497-30-3

Ergothioneine powder is a natural molecule, which was isolated from ergot fungus in rye and later found in red blood cells, liver and many other animal tissues of rats. As a natural antioxidant, it can protect cells in human body and is an important active substance in the body. With the development of modern science and technology, its antioxidant properties can not only provide the therapeutic potential of this compound, but also be used as food additives or cosmetic raw materials.

What are the action principles of Ergothioneine in organisms? 

According to the relevant scientific research documents, L-(+)-Ergothioneine is distributed in some tissues and organs of mammals, mainly in red blood cells (about 1 ~ 2 mmol L) and semen of some animals. Although there is no experimental study showing that animals can synthesize this substance, there must be ways to absorb and retain L-Ergothioneine in animal cells. For carnivores, L-(+)-ERGOTHIONEINE INNER SALT in animal tissues can supply dietary needs, and it has been found that it has a similar structure in some cereal plants. According to the latest research, we can know that THIONEINE is transported into mitochondria through the transporter OCTN1 on cell membrane and mitochondrial membrane. Mitochondria are called by researchers as an important "energy factory" to maintain life activities. In mitochondria, natural EGT can play an antioxidant role, inhibit DNA damage, effectively protect against ultraviolet damage, protect cells and prevent photoaging. At the same time, it also has the ability to scavenge free radicals, reduce lipid peroxidation and promote the body's own antioxidant enzymes. In the comparison of different products, Ergothioneine powder is haunters, which can PK off the same type of players, such as coenzyme Q10 and idebenone. Taking hypochlorous acid reaction as an example, we know that many compounds can react with hypochlorous acid, but few can react so quickly as ERGOLD. For example, the a1- antiprotease inhibitor (API) of elastase is particularly sensitive to hypochlorous acid, and ergothione with physiological concentration can effectively protect the API against inactivation caused by hypochlorous acid. Because neutrophils are the main source of hypochlorous acid in the body, one of its functions is to protect red blood cells from the harm of neutrophils from normal function or pathological inflammatory sites.

What are the applications of Ergothioneine?

Ergothioneine powder is a powerful hypochlorous acid scavenger (HOCl). At present, the main synthetic route is through some bacteria and fungi. It is an imidazole -2- thione derivative of histidine betaine. At present, it has a wide range of uses and market prospects in the fields of organ transplantation, cell preservation, medicine, food and beverage, functional food, animal feed, cosmetics and biotechnology. It is also a highly protective and non-toxic natural antioxidant for cells, which is not easy to be oxidized in water, which makes their concentration in some tissues reach m mol and stimulates the natural antioxidant defense system of cells. Among many antioxidants, L-Ergothioneine is particularly unique because it can chelate heavy metal ions and protect red blood cells from free radical damage. However, It also has certain risks to pay attention to in use.
1. Allergy to EGT or its derived food (such as fungi) will cause allergic symptoms such as rash, itching, dyspnea and hypotension;
2. Excessive intake of EGT can stimulate gastrointestinal mucosa, causing discomfort such as stomach pain, nausea, vomiting and diarrhea;
3. EGT will seriously affect the body's absorption of vitamin B12. Long-term extensive use will increase the risk of vitamin B12 deficiency, leading to anemia and nervous system problems.

What is the marketization process of EGT?

L-Ergothioneine can achieve cross-border development in cosmetics, food, functional food and biomedicine. According to the research of relevant institutions, the global market size of ergothionine is about 130 million yuan in 2021, and it is expected to reach 1.1 billion yuan in 2028, which shows that ergothionine powder is an anti-aging component with a very high development boom.
Among them, cosmetics are one of the most widely used fields of EGT. The United States and Europe are the largest markets where EGT is used. They regard EGT as the fifth generation antioxidant and use it in all kinds of big-name cosmetics. Since 2014, China EGT has been listed in the catalogue of cosmetic raw materials by the State Food and Drug Administration, which has deepened the research and application of EGT.

At present, although EGT has not been applied to food in China, it has been applied to food in Europe, America, Japan and other countries and regions.

In addition, L-EGT aqueous solution also has good food preservation effect. The results showed that the browning of postharvest Agaricus bisporus could be slowed down and the shelf life could be prolonged by treating it with L-EGT solution.

L-EGT aqueous solution extracted from Flammulina velutipes can be used to inhibit the production of methemoglobin in bigeye tuna meat, prevent lipid peroxidation of tuna meat and keep its bright color. At low temperature, mushroom extract rich in L-EGT can inhibit lipid oxidation of salmon muscle tissue.

In 2016, the European Union issued the safety statement of L-EGT as a food additive, which further broadened the road for the application of L-EGT in food preservation.

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