Carnosic Acid Powder CAS 3650-09-7

Carnosic acid is a diterpenoid compound isolated from the leaves of the plant Rosmarinusofficinalis. High purity Carnosic acid is a white, yellowish white, or viscous yellow powder that is easily soluble in oils and organic solvents such as ethanol, ethyl acetate, acetone, chloroform, and insoluble in water. Carnosic acid powder is suitable for antioxidant properties of oil soluble components. Used in sauces, pet food, and feed, it has antioxidant and anti-aging effects; Strong weight loss and lipid-lowering effects; Treat cardiovascular diseases and have anti-cancer effects.

What are the research progress on the biological activity of Carnosic acid powder? 

Carnosic acid powder is the main component of rosemary, a labiatae plant. As an efficient natural antioxidant, it not only has antioxidant and anti-aging effects, but also has neuroprotective and anti-osteoporosis effects.
1. Neuroprotection
Scientists treated dopamine neurons cultured in vitro with MPTP(10μmol/L), and found that after MPTP treatment, neurons shrank, axons broke, dendrites decreased, neuron vitality decreased, neuron caspase-3 mRNA and protein expression increased significantly, MDA content and LDH leakage in culture medium increased significantly, and neuron SOD activity decreased significantly. However, pretreatment with carnosic acid can reverse the morphological atrophy and activity decrease of neurons induced by MPTP. At the same time, it can reverse the abnormal increase of caspase-3 mRNA and protein in neurons induced by MPTP. Reduce MDA content and LDH leakage; The activity of SOD in neurons was enhanced, which indicated that carnosic acid had protective effect on dopaminergic neurons induced by MPTP. Because carnosic acid can reduce the MDA content and LDH leakage of MPTP-induced dopaminergic neurons and enhance the SOD activity of neurons, the research team speculated that the protective effect of carnosic acid on Parkinson's disease may be related to antioxidant damage.
2. Inhibition of osteoporosis
It is found that carnosic acid can inhibit the differentiation and function of osteoclasts induced by RANKL. In the osteoporosis model caused by estrogen deficiency in menopause in ovariectomized mice, the expression levels of serum alkaline phosphatase (ALP), osteocalcin (BGP), tartrate-resistant acid phosphatase (strACP) and collagen C-terminal peptide I (CTX-1) decreased after 16 weeks of using carnosic acid, and the calcium ion remained stable, while the phosphorus content increased obviously. These results were consistent with those of estradiol valerate. Micro-CT/TRAP staining analysis of tibia/femur in mice showed that carnosic acid could prevent bone loss caused by ovariectomy by inhibiting the formation of osteoclasts.
Follow-up studies also show that, on the one hand, it can reduce cholesterol biosynthesis by inhibiting targeted sterol regulatory element binding protein 2(SREBP2, a major regulator of cholesterol synthesis); On the other hand, it can also significantly reduce the protein level of ERRα, and at the same time reduce the interaction between ERRα and γ coactivator 1-β(PGC1β) activated by peroxisome proliferator, resulting in the decrease of the transcription activity of ERRα and the expression of its target gene.

Why is Carnosic Acid Powder called a multi life antioxidant?

Carnosic acid powder is a natural diterpenoid compound. Carnosic acid powder with high purity is white or yellowish white, which is soluble in oils and organic solvents and insoluble in water. Carnosic acid is suitable for high oxidation resistance of oil-soluble components, and its oxidation resistance effect is obvious. Moreover, this product can resist high temperature, is safe and non-toxic, and is still stable at 200℃ and has oxidation resistance, which makes it still applicable in some special food processing technologies, such as boiling, frying, frying and baking, and is regarded as a multi-life antioxidant.
1. Stabilize oil and prolong storage time. It can prevent or delay the oxidation of grease or oily food, improve the stability of food and prolong the storage time of stored products. One of our partners, Infinite Chicken Wings, uses carnosic acid to extend the shelf life of food without changing its flavor.

2. As a flavoring agent for meat and fish. It can prevent the oxidation of meat products such as ham and sausage.

3. It can inhibit the fishy smell of frozen fish and meat products.

4. Prevent oxidation in high-temperature fried food and prevent light deterioration after packaging.

What is the significance of the application of rosemary extract and related products in livestock breeding?

1. Research shows that rosemary extract can increase the daily gain of Jinghai yellow chicken, reduce the feed-to-weight ratio and significantly improve its growth performance, especially at 0-4 weeks old. Adding 200mg/kg(0.02%) carnosic acid powder to the diet significantly improved the total antioxidant capacity of serum. Adding 200mg/kg(0.02%) rosmarinic acid and carnosic acid to the diet significantly reduced the content of serum impurities.
2. The results showed that adding 150mg/kg(0.015%) rosemary essential oil to the diet could improve the meat quality and antioxidant capacity of Jinghai yellow chicken, increase the meat color, reduce the water loss rate and shear force, increase the activities of serum glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD), and gradually reduce the content of harmful substances.
3. The study showed that adding 500mg/kg(0.05%) rosmarinic acid to the diet can significantly reduce the diarrhea rate of weaned piglets, alleviate the colon inflammatory reaction caused by ETEC K88 (enterotoxin-producing Escherichia coli ETEC K88 can release enterotoxin, which is one of the important causes of diarrhea in piglets), and reduce the contents of inflammatory factors IL-1β and TNF-α in the colon mucosa of piglets.
4. The research shows that adding 300mg/kg coated rosemary essential oil to the diet can significantly reduce the feed conversion efficiency FCR and reduce the diarrhea rate; Significantly increased superoxide dismutase SOD and glutathione peroxidase GSH-Px, and improved serum antioxidant capacity.

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