Chrysophanol CAS 481-74-3

At present, the pharmacological effects of Chrysophanol show that it can further protect the nervous system of rats with ischemia-reperfusion injury by inhibiting the expression of proinflammatory factors. Play an antioxidant role by regulating superoxide dismutase and glutathione; It can inhibit the migration and metastasis of oral cancer cells.

Study on neuroprotective effect

In recent years, there have been more and more studies on the neuroprotection of this product, and its mechanism mainly includes inhibiting neuronal apoptosis, enhancing antioxidant enzyme activity, inhibiting cholinesterase activity, and down-regulating the expression of inflammatory factors. Alzheimer's disease (AD) is a neurodegenerative senile disease, the main clinical manifestations are slow movement, memory loss, aphasia and other symptoms.

Because of its complicated pathogenesis, Chrysophanol is usually the result of multiple factors (including physiology and environment). Up to now, there are still no drugs with clear mechanism for treatment in clinic. With the more and more in-depth research on traditional Chinese medicine and its extracts, it is found that it has certain pharmacological activity on Alzheimer's disease.

Study on antioxidant effect

Oxidative stress and antioxidation are ubiquitous in the body. Once they are out of balance, diseases may be caused, but the restoration of balance between them will have a positive impact on the treatment of diseases. With the in-depth study of this product, its antioxidant activity is also more significant. It can reduce the damage of free radicals to cells by enhancing the activity of antioxidant enzymes. At the same time, Chrysophanol can improve the dysfunction of astrocytes. This provides a new therapeutic strategy for oxidative stress injury.

Study on anticancer effect

In recent years, studies have shown that chrysophanol shows certain anticancer activity. The researchers showed that chrysophanol significantly increased the production of reactive oxygen species (ROS) in human ovarian clear cell cancer cells and activated the mitogen-activated protein kinase signal pathway, which indicated that this product had the potential to treat ovarian cancer. It shows certain activity in colon cancer, breast cancer, lung cancer, T-cell acute lymphoblastic leukemia, ovarian cancer, liver cancer and so on, Chrysophanol can provide new research direction and basis for clinical development of drugs for treating cancer.