What is Asiatic acid?
Asiatic acid is a pentacyclic triterpenoid compound found in Centella asiatica, which has anti-cancer and anti-inflammatory activities.
Asiatic acid can induce apoptosis in melanoma cells and has a barrier protective effect on human aortic endothelial cells (HAEC). It can also inhibit endothelial barrier dysfunction induced by tumor necrosis factor (TNF) - α, as well as NLRP3 inflammasome activation and NF - κ B pathway, effectively suppressing inflammation in rats and exhibiting neuroprotective effects in a rat spinal cord injury (SCI) model
| Product name | Asiatic acid |
| CAS | 464-92-6 |
| Molecular formula | C30H48O5 |
| Molecular weight | 488.7 |
| EINECS Number | 482-720-9 |
| Storage condition | 2-8°C |
| Melting point | 325-330 °C(lit.) |
| Solubility | Soluble in methanol at 1mg/mL, transparent, colorless |
| Appearance | White Powder |
| Boiling point | 609.4±55.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
How to extract Asiatic acid?
Asiatic Acid is mainly found in plants such as Centella asiatica. The method of extracting oxalic acid from snow usually involves the following steps:
1. Preparation of plant materials:
Choose fresh or dry snow grass plants. Clean and dry plant materials to remove impurities and moisture.
2. Extraction method:
Solvent extraction method: Organic solvents such as methanol, ethanol, dimethyl sulfoxide, etc. are used for extraction. After crushing the dried plant materials, add an appropriate amount of solvent and extract oxalic acid from snow by soaking, stirring, or ultrasound assisted methods.
Acid hydrolysis method: Asiatic acid is a glycoside of Asiatic glycoside, which can be obtained by hydrolyzing the sugar part of Asiatic glycoside structure under acidic conditions.
3. Purification and Separation:
Column chromatography: Purification and separation of the extract using silica gel column chromatography or other suitable chromatographic methods.
Recrystallization: Recrystallize the purified oxalic acid solution to improve purity.
High performance liquid chromatography (HPLC): Use HPLC for further purification and quantitative analysis.
4. Drying and storage:
The purified asiatic acid solution is dried, usually by freeze drying or spray drying. Store the dried snow oxalic acid powder in a dry and dark environment to prevent degradation.
Product Specification
| Items |
Specification |
Results |
| Physical Analysis | ||
| Appearance | Fine Powder | Conforms |
| Color | White Powder | Conforms |
| Odor | Characteristic | Conforms |
| Mesh Size | 100% through 80% mesh size | Conforms |
| General Analysis | ||
| Identification | Identical to R.S. sample | Conforms |
| Dihydromyricetin | ≥90% | 90.56% |
| Extract Solvents | Water | Conforms |
| Loss on Drying (g/100g) | ≤5.0 | 2.38% |
| Ash(g/100g) | ≤5.0 | 3.59% |
| Chemical Analysis | ||
| Pesticides Residue (mg/kg) | 0.05 | Conforms |
| Residual Solvent | <0.05% | Conforms |
| Residual Radiation | Negative | Conforms |
| Lead(Pb) (mg/kg) | <3.0 | Conforms |
| Arsenic(As) (mg/kg) | <2.0 | Conforms |
| Cadmium(Cd) (mg/kg) | <1.0 | Conforms |
| Mercury(Hg) (mg/kg) | <0.1 | Conforms |
| Microbiological Analysis | ||
| Total Plate Count(cfu/g) | ≤1,000 | 300 |
| Molds and Yeast (cfu/g) | ≤100 | 30 |
| Coliforms (cfu/g) | Negative | Conforms |
| Salmonella(/25g) | Negative | Conforms |
Conclusion：Conform with enterprise specification .
What are the effects of Asiatic Acid?
Asiatic Acid powder is a pentacyclic triterpenoid compound with multiple pharmacological functions and potential therapeutic effects. Here are some of the main effects of oxalic acid in snow:
1. Anti inflammatory effect: Asiatic acid has significant anti-inflammatory effects and can alleviate inflammatory reactions, making it suitable for treating various inflammatory diseases.
2. Antioxidant effect: It is also an effective antioxidant that can clear free radicals and reduce the damage of oxidative stress to the body.
3. Promote wound healing: Asiatic acid can promote the healing process of skin wounds and has a certain effect on the treatment of skin injuries such as burns and wounds.
4. Antitumor effect: Studies have shown that oxalic acid also has certain anti-tumor effects, which can inhibit the growth and spread of tumor cells.
5. Neuroprotective effect: In preclinical trials, oxalic acid has shown neuroprotective behavior and may have certain therapeutic potential for neurological diseases.
6. Cardioprotective effect: In preclinical trials, oxalic acid has shown cardioprotective behavior and may have certain preventive and therapeutic effects on cardiovascular diseases.
7. Lowering blood pressure and blood sugar: Centella asiatica also shows the behavior of lowering blood pressure and blood sugar, which may be beneficial to the management of chronic diseases such as hypertension and diabetes.
8. Antimicrobial effect: Asiatic acid has antimicrobial activity and can inhibit the growth of certain bacteria and fungi.
In summary, oxalic acid powder is a multifunctional compound with various pharmacological activities that make it widely applicable in the fields of medicine and cosmetics. However, it should be noted that these effects are mainly based on the results of in vitro studies and animal experiments, and their safety and efficacy in humans need further clinical trials to confirm.
How and where to buy Asiatic Acid wholesale?
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Note: This compound is only used for laboratory research purposes. The US authorities have not evaluated these claims. Before use, please consult your doctor and learn about available research. This product is not intended for the diagnosis, treatment, cure, or prevention of any disease.
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