Orforglipron Powder CAS 2212020-52-3

Orforglipron Introduction

Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.

As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.

Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East. 

Orforglipron powder is a small-molecule compound with a complex structure, appearing as an off-white to pale yellow powder (CAS: 2212020-52-3; molecular formula: C48H48F2N10O5; molecular weight: 882.97; EINECS: 278-636-5). It is primarily indicated for the treatment of obesity (in non-diabetic patients) and type 2 diabetes; results from Phase III clinical trials have been positive, demonstrating significant, dose-dependent efficacy.

What are the uses of orforglipron?

Orforglipron powder is a newly synthesized oral non-peptide compound that can regulate blood sugar levels by promoting glucose-dependent insulin secretion and balancing the body's energy metabolism. In early animal experiment models, this substance has shown remarkable effects in improving the hyperglycemic state of experimental subjects, and it also possesses metabolic characteristics suitable for oral administration.
This compound is currently mainly focused on research related to adult blood sugar regulation and weight management. The related phase III trials were officially launched in September 2023. The data from the phase I trial indicates that it has similar effects to GLP-1-related substances and can be applied in studies related to obesity and type 2 diabetes. Its overall performance is at the same level as similar GLP-1 active substances.
The results of the phase II trial further confirmed that it can significantly optimize the glycosylated hemoglobin indicators and help control weight. The observed adverse reactions are consistent with those of mainstream GLP-1 receptor agonists. Its metabolic characteristics support daily single-dose oral administration, and during use, there is no need for deliberate dietary or fluid control, providing a safe and convenient oral research solution for related research directions.
Most related preparations in the same field currently adopt non-oral forms, while this oral compound has a lower usage threshold, higher acceptance among the audience, and can also avoid the resistance of some people to the conventional administration method. Its application advantages are very obvious.

What is the mechanism of action of orforglipron?

Orforglipron powder is an oral, non-peptide small molecule that selectively binds to and activates the human glucagon-like peptide-1 receptor (GLP-1R). It exhibits unique biased signaling properties, preferentially activating G-protein pathways involved in metabolic regulation and increasing intracellular cyclic AMP (cAMP) levels.
This mechanism enhances glucose-stimulated insulin secretion, inhibits glucagon release, slows gastric emptying, and reduces appetite. Crucially, it does not significantly activate β-arrestin-a protein associated with receptor desensitization-thereby allowing for sustained therapeutic effects.
By targeting GLP-1 receptors in tissues such as the pancreas, brain, and gastrointestinal tract, the product achieves the dual benefits of blood glucose regulation and weight management. As a small-molecule agent, it offers an oral bioavailability of approximately 79%, requires no strict dietary restrictions, and supports a convenient once-daily dosing regimen.

MF of orforglipron

CAS	2212020-52-3
EINECS	278-636-5
Molecular formula	C48H48F2N10O5
Molecular weight	882.97
Density	1.50±0.1 g/cm3

Specification

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Orforglipron Powder etc. at a more favorable price. If you are interested, please leave a message. 
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FAQ: 

Q1:What is the biggest difference between Orforglipron and existing GLP-1 products like Semaglutide?
It is a small-molecule product rather than a peptide; therefore, it exhibits high oral bioavailability  and is not affected by food or water intake.
Q2: What are the side effects of orforglipron?
The most common adverse reactions (incidence ≥5%) include nausea, constipation, diarrhea, vomiting, dyspepsia, abdominal pain, headache, abdominal distension, fatigue, eructation, gastroesophageal reflux disease, flatulence, and alopecia.
Q3:Which body tissues does orforglipron affect?

GLP-1 receptors, which can act on tissues in various locations such as the pancreas, brain, and gastrointestinal tract.

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