DSIP CAS 62568-57-4

DSIP is a peptide composed of nine amino acids, and Its amino acid sequence is: Trp-Ala-Gly-Gly-ASP-Ala-SER-Gly-Glu(WAGGDASGE); It has been proved in some studies that it is a neuropeptide with antioxidant and anti-anxiety effects. It is used to improve and induce sleep in clinic, and the effect is very ideal.

Product Specification

What is Delta-Sleep Inducing Peptide?

In 1974, the Schoenenberger-Monnier team in Switzerland first isolated Delta Sleep Inducing Peptide from the cerebral venous blood of rabbits in induced sleep. Researchers also take it for granted that the rabbit's sleep has something to do with it.
In further research, when the isolated pure dsip product was put into the midbrain ventricle of the recipient rabbit (awake rabbit), the researchers found that it would induce spindle wave and Delta EEG activity, and reduce the physiological activity of the rabbit. However, there have been contradictions in the study of this theme. Although it can obviously induce slow-wave sleep in rabbits, the gene sequence of the peptide has not been found in rabbits (including any receptor or precursor peptide). Later, a substance similar to DSIP was found in human breast milk.

Can DSIP easily cross the blood-brain barrier?

The Delta-sleep inducing peptide is a linear nine membered short peptide (as shown in the figure), and the molecular weight of DSIP is an amphiphilic peptide with a molecular weight of 850 daltons. This peptide can act as a stress limiting factor and may have antioxidant effects. In experiments with other animals, we found that it can improve sleep efficiency and shorten sleep latency. In observational studies using humans as carriers, it has been found that natural DSIP can alleviate migraines, vasomotor headaches, etc. (researchers believe that it can more easily cross the blood-brain barrier). At the same time, it can stimulate the secretion of luteinizing hormone to increase testosterone levels, indirectly helping to alleviate pain symptoms. It is inferred that using DSIP to treat withdrawal symptoms of alcohol and certain products in the future is an ideal choice.In addition to dsip, our company can also provide further help for your withdrawal reaction. If you wish to obtain assistance, please contact us by email:email: sales6@faithfulbio.com

Why can Delta Sleep Inducing Peptide cross the blood-brain barrier with a full body appearance?

Blood-brain barrier refers to the barrier between plasma and brain cells formed by brain capillary wall and glial cells and between plasma and cerebrospinal fluid formed by choroid plexus, which can prevent some substances (mostly harmful) from entering brain tissue from blood. It acts like a team of loyal aircraft security personnel, and anyone who fails to comply with the regulations cannot pass. These irregularities include most peptide molecules.
When researchers were studying the source of δ sleep-inducing peptide, they were surprised to find that DSIP can completely cross the blood-brain barrier through advanced radioimmunoassay analysis.
In the process of answering the question about the mechanism by which DSIP crosses the blood-brain barrier, which is regarded as a "natural barrier" by most polypeptide molecules, the researchers found that although these peptides are comparable in molecular weight, their ability to enter the central nervous system is very different. In the case of similar molecular sizes, such a huge difference in transport speed shows that molecules do not cross the blood-brain barrier by relying on passive diffusion mechanism. On the contrary, fat solubility is a key index of the rate of entering the brain: many peptides can cross the blood-brain barrier by virtue of their high lipophilicity. This may be another exception to the Lipinski 5 rule. (Molecules with molecular weight less than 500 Da can cross the blood-brain barrier better than those with molecular weight greater than 500 Da. )
Up to now, the largest substance crossing the blood-brain barrier through unsaturated mechanism (drugs enter the brain through active transport or special receptor-mediated channels, rather than passive diffusion mechanism) is CINC-1 (a cytokine involved in the regulation of inflammation and immune response), with a molecular weight of 7.8 kDa .

What is the latest research on the interaction and function of this product?

This substance exists in the hypothalamus, limbic system, pituitary gland and various peripheral organs, tissues and body fluids in free and combined forms.
In the pituitary gland, it interacts with many peptide and non-peptide mediators, such as adrenocorticotropic hormone-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte stimulating hormone (MSH), thyroid stimulating hormone (TSH) and melanin concentrating hormone (MCH).
It is abundant in intestinal secretory cells and pancreas and combines with glucagon.
In vitro, due to the action of specific aminopeptidase-like enzymes, it was found that its molecular stability was low and its half-life was only 15 minutes. Some scientists speculate that this substance may be combined with carrier protein in vivo to prevent degradation, or exist as a part of large precursor molecules, but so far no structure or gene of this precursor has been found.
At present, the popular inference is that DSIP interacts with the components of MAPK cascade, which is homologous to glucocorticoid-induced leucine zipper (GILZ) and may be regulated by glucocorticoid.
In clinical trials, DSIP has many functions: it can reduce the level of basic corticotropin and prevent its release; Stimulate the release of luteinizing hormone (LH); Stimulate the secretion of growth hormone releasing hormone and growth hormone, and inhibit the secretion of somatostatin.
In the physiological process, it can be used as a pressure limiting factor to normalize blood pressure and myocardial contraction.
It may have a direct or indirect effect on body temperature and relieve hypothermia. It can enhance the oxidative phosphorylation efficiency of rat mitochondria in vitro and may have an antioxidant effect.
Some studies have shown that DSIP is related to promoting slow-wave sleep (SWS) and inhibiting rapid eye movement sleep (REM), and the synthetic DSIP analogues also have a strong influence on sleep.
It may affect the function of human lens epithelial cells through MAPK pathway, which is involved in cell proliferation, differentiation, movement, survival and apoptosis.

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