Transdermal Peptide TD-1 HCl CAS 918629-48-8

Transdermal Peptide Introduction

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Transdermal Peptide TD-1 HCl is an artificially synthesized small molecule cosmetic peptide. The entire peptide chain consists of 11 amino acids, with the corresponding sequence being ACSSSPSKHCG. Its normal appearance is a white powder. CAS number: 918629-48-8; Molecular weight approximately 1063.17; Molecular formula: C40H66N14O16S2; The standard purity for scientific research use is at least 95%, and it needs to be stored at -20℃ for a long time.
This peptide is not a natural extract. In 2006, Professor Wen Longping from the University of Science and Technology of China, with the help of in vivo phage display screening technology, isolated it from a massive peptide library. Transdermal Peptide is also the first peptide that has been experimentally proven to be able to bind to the sodium-potassium ATPase β subunit of skin cells, and can reversibly loosen the skin's keratin barrier, thereby assisting the penetration of macromolecular substances through the epidermis.
At present, TD-1 is mainly used as a transdermal penetration enhancer: In the field of biomedicine, it can enhance the percutaneous absorption effect of protein-based preparations such as insulin and growth hormone, and also opens up new ideas for percutaneous product delivery treatment of superficial lesions; In the skincare and cosmetic application scenarios, Transdermal Peptide is often used to accelerate the penetration of skin care active ingredients, strengthen the repair and anti-aging-related effects.

How does the transdermal peptide work?

The Transdermal peptide TD-1 HCl achieves its permeation-promoting effect based on a clear molecular target and biological action pathway. This peptide can specifically bind to the sodium-potassium ATPase β subunit ATP1B1 of epidermal cells, with the binding site concentrated in the C-terminal region of this protein. After binding, it alters the expression distribution of the ATP1B1 protein, indirectly adjusting the structure of the epidermal layer, and temporarily forming reversible microchannels and intercellular spaces at the skin barrier, allowing large molecule active substances such as INSULIN to penetrate the skin smoothly.
The entire action process does not directly combine with the compound to be delivered. The strength of the effect is influenced by both the peptide chain sequence and the dosage used. It also requires a normal body temperature environment for it to take effect. If an ATP1B1 competitive binding agent or a sodium-potassium ATPase inhibitor like wabacinin is added, the transdermal enhancing effect of TD-1 will be completely blocked.

What is the function of Transdermal Peptide?

The core function of Transdermal Peptide TD-1 HCl is as a transdermal penetration enhancer, which helps large-molecule active substances pass through the skin barrier. These substances are difficult to penetrate the epidermis on their own.
In the field of active delivery research, simply combining TD-1 with the active ingredients and using them simultaneously can assist insulin penetration, increase the insulin content in the body, and steadily lower blood sugar levels. It can also promote certain large-molecule substances in the human body to enter the circulation, providing a feasible direction for creating non-invasive, non-intrusive skin patch preparations.  
Whether it is external intervention or skincare research, Transdermal Peptide can be used as a universal supporting technology to pair with various active substances: for example, when combined with liposomes encapsulating Curcumin, it can significantly enhance the penetration ability of the active substance in the mouse melanoma model, inhibiting the proliferation of the lesion; in 2024, related experiments will combine TD-1 with the whitening active Glutathione to verify that this complex can efficiently penetrate the living skin tissue and reduce melanin production.

MF of Transdermal Peptide

CAS	918629-48-8
Molecular formula	C40H66N14O16S2
Molecular weight	1063.17
Density	1.450±0.06 g/cm3
Boiling point	1710.6±65.0 °C

Specification

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FAQ: 

Q1:What substance can counteract the penetration-enhancing effect of Transdermal Peptide?
The ATP1B1 competitive inhibitors of sodium-potassium ATPase directly block the transdermal enhancing effect of TD-1.
Q2:Will Transdermal Peptide undergo a binding reaction with the delivered active ingredient?
No, there is no direct interaction between the two. The penetration-promoting effect is achieved solely by regulating the skin structure through the peptide itself.
Q3:Does Transdermal Peptide have any side effects?

When used properly and on the entire skin, Transdermal Peptide has no persistent toxic side effects. Only when applied at extremely high concentrations, on damaged skin, or in combination with highly irritating ingredients, will there be temporary redness and itching. These symptoms will quickly subside upon discontinuation.

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