Pentapeptide-3 Raw Powder CAS 725232-44-0

Palmitoyl Pentapeptide-3 is a synthetic active peptide consisting of five amino acid residues, with a CAS number of 135679-88-8 and a molecular weight of approximately 495.58-569.7 g/mol. Its amino acid sequence is K-T-T-K-S (lysine-threonine-threonine-lysine-serine), which exhibits strong positive charge at physiological pH and can interact with negatively charged biomolecules on the skin, enhancing its effect. The Pentapeptide-3 Raw Powder we provide has undergone palmitoylation modification, significantly enhancing its transdermal absorption capacity and improving its bioavailability.

What is the mechanism of action of Pentapeptide-3 Raw Powder?

Palmitoyl Pentapeptide-3 Raw Powder exerts anti-aging effects through multiple mechanisms:
1. Promote collagen synthesis: It can activate the TGF - β signaling pathway, stimulate fibroblast proliferation, upregulate the expression of type I, III collagen and elastin genes, inhibit matrix metalloproteinase MMP-1 activity, and reduce collagen degradation
2. Antioxidant synergistic effect: It can chelate metal ions to inhibit ROS generation, and it can also increase free radical scavenging rate by 40% when combined with vitamin C/E
3. Regulating extracellular matrix: It can regulate the balance between MMPs and TIMPs, reduce extracellular matrix degradation, maintain skin firmness and elasticity. In addition, compared to some fast acting but high-risk anti-aging ingredients, it does not directly paralyze muscles, but instead causes muscle relaxation by blocking sodium ion release. At the same time, it can also reduce muscle contraction by reversibly blocking nerve signals, with a mild effect and suitable for daily maintenance.

What are the process optimizations for Pentapeptide-3 Raw Powder?

Pentapeptide-3 has shown good stability in skincare products and has been tested for thermal stability and pH tolerance. Palmitoyl Pentapeptide-3 Raw Powder can tolerate pH 4-9 acidic and alkaline environments, and its activity retention rate still exceeds 95% after being treated at high temperature of 80 ℃ for 2 hours, which can meet the requirements of hot filling process. Its cyclic structure is more stable than linear peptides, and the degradation rate is less than 8-12% after incubation in serum for 48 hours. But this does not guarantee that it can withstand the test of time. Therefore, reasonable formula design and storage conditions are needed to ensure its activity. The following are commonly used strategies for maintaining activity:
1. Freeze drying technology: The use of freeze-drying process can significantly improve stability. By rapidly freezing (≤ -80 ℃, rate ≥ 20 ℃/min) to form small ice crystals, combined with trehalose (3-5%) and sucrose (2-4%) as glass transition protectants, the activity retention rate after freeze-drying can be ≥ 90%. The final moisture content should be controlled at ≤ 3% to ensure long-term storage stability.
2. Nanocarrier technology: By using liposome encapsulation technology, the transdermal rate can be increased to 78%, which is 2.3 times higher than traditional formulations, while enhancing the dispersibility and stability of ingredients in the formulation.
Through the above comprehensive measures, pentapeptide-3 can maintain stable biological activity in skincare products and achieve long-lasting anti-aging effects.

What is the transdermal rate of pentapeptide-3 in skincare products?

The penetration rate of Vialox peptide in skincare products is excellent, with an in vitro penetration rate of over 89%, which can deeply penetrate into the dermis layer and exert its effects. Its molecular weight is about 539.64, and it has strong positive charge at physiological pH. It can interact with negatively charged biomolecules on the skin to enhance transdermal absorption.
In addition, the use of palmitoylation modification (such as palmitoyl pentapeptide-3) can further enhance transdermal absorption capacity, and lipid chains can break through the stratum corneum barrier, resulting in a 5-fold increase in transdermal rate compared to non acylated peptides. These technological methods enable pentapeptide-3 to efficiently penetrate into the dermis, activate fibroblasts, promote collagen and elastin synthesis, and achieve a delay in photoaging and glycation damage from the source.
If liposome encapsulation technology is used, the transdermal rate of Pentapeptide-3 Raw Powder can be further increased to 78%, which is 2.3 times higher than the traditional formula. Liposome technology is based on the phospholipid bilayer structure, simulating the characteristics of biological membranes to achieve encapsulation and sustained release of active substances. It can effectively integrate the lipid structure of the stratum corneum and promote peptide penetration through the skin barrier.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Pentapeptide-3 Raw Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

FAQ:

Q1: How to dissolve it?
Pentapeptide-3 has a certain solubility in water and can be configured into an aqueous solution for experimentation or product formulation. To promote dissolution, appropriate stirring or ultrasonic treatment can be used, but the time should not be too long to avoid degradation of peptide chains due to excessive mechanical action.
Q2: Does pentapeptide-3 raw powder have any effect on wound healing?
Research has shown that pentapeptide-3 also exhibits potential in wound healing studies, possibly by promoting granulation tissue formation, accelerating wound healing processes, and reducing scar formation. But it is still in the animal experimental stage and needs further clinical research to confirm.
Q3: Can it replace sunscreen products?
No. The pentapeptide-3 products are not labeled with SPF values, and the antioxidant components cannot completely block ultraviolet radiation. Daytime use requires the addition of SPF 30+sunscreen ingredients.

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