Met-Enkephalin-Arg-Phe CAS 73024-95-0
Product Name:MET-ENKEPHALIN-ARG-PHE
Synonym:[Met5]enkephalyl-Arg-Phe;L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Phe-OH;Tyr-Gly-Gly-Phe-Met-Arg-Phe-OH;Met-Enkephalin-Arg-PheMERChemicalbookF;MethionineEnkephalin-Arg-Pheacetatesalthydrate;Tyr-Gly-Gly-Phe-Arg-Arg-Phe;Met-Enkephalin-RF;arg(6)-phe(7)-enkephalin-me
CAS NO.:73024-95-0
EINECS NO.:000-000-0
Molecular Formula:C42H56N10O9S
Purity & Grade: 99%; Medicine grade
Character:White Powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 5-10 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description

Met-Enkephalin-Arg-Phe CAS 73024-95-0, or MERF for short, is an endogenous heptapeptide opioid peptide widely found in the central nervous system and peripheral tissues of humans and various mammals. It is produced by the specific enzymatic cleavage of proenkephalin A and is an important component of the endogenous analgesic system. As a naturally occurring bioactive peptide, it plays an indispensable role in the body's physiological regulation, and its unique structure and function make it a research hotspot in neuroscience and physiology.
MERF's mechanism of action is highly specific. It primarily binds to μ-opioid receptors with high affinity, thereby activating Gi/Go proteins in the body, inhibiting adenylate cyclase activity, reducing intracellular cAMP levels, and simultaneously regulating the opening and closing of ion channels, inhibiting voltage-gated calcium channels, and opening potassium channels, leading to neuronal hyperpolarization and thus inhibiting pain signal transmission to achieve its physiological function. Currently, research on MERF mainly focuses on pain mechanisms, receptor pharmacology, and neuroscience. As a natural bioactive peptide, it provides an important research subject for the study of endogenous analgesic systems, and also provides an important tool molecule for the exploration of related physiological mechanisms and subsequent scientific research. It helps people to understand the physiological regulatory mechanisms of the body more deeply and promotes research progress in related fields.

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COA
| Tests | Specifications | Results |
| Appearance | White Powder | White Powder |
| Assay | 99%min | 99.56% |
| Heavy metal | 10ppm max | 8.9ppm |
| Single impurity | 0.2%max | Complies |
| Loss on drying | 0.5%max | 0.48% |
| Conclusion | Conform with enterprise specification | |
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Density 1.38 g/cm³
Molecular Formula C42H56N10O9S
Molecular Weight 877.02
Exact Mass 876.39500
PSA 345.35000
LogP 3.25660
Mechanism of Action of Met-Enkephalin-Arg-Phe CAS 73024-95-0
Receptor Binding: Binds to μ-opioid receptors (MOR) with high affinity.
Signaling Pathway: Activates Gi/Go proteins, inhibits adenylate cyclase (AC), and reduces cAMP levels.
Ion Channels: Inhibits voltage-gated calcium channels, opens potassium channels, leading to neuronal hyperpolarization and inhibiting pain signal transduction.
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FAQ
01. What are the main physiological functions of Met-Enkephalin-Arg-Phe CAS 73024-95-0?
It mainly participates in analgesia and regulates pain transmission. It is also related to mood regulation, stress response, cardiovascular activity, gastrointestinal motility, and immune regulation.
02. Where is Met-Enkephalin-Arg-Phe CAS 73024-95-0 mainly distributed in the body?
It is widely distributed in the central nervous system (brain, spinal cord) and peripheral tissues, such as the gastrointestinal tract, sympathetic ganglia, and cardiovascular tissues.
03. Where can I buy Met-Enkephalin-Arg-Phe CAS 73024-95-0?
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