What is Trofinetide?
Trofinetide is a synthetic analogue of amino-terminal tripeptide of insulin-like growth factor, which aims to contribute to the core symptoms of Rett syndrome by reducing neuroinflammation and supporting synaptic function. In March 2023, it was approved by the US FDA.
Trofinetide is suitable for adults and children over 2 years old with Reiter's syndrome. Reiter's syndrome is a rare hereditary neurodevelopmental disorder, mainly caused by the mutation of MECP2 gene, which affects the development of nervous system and leads to motor, cognitive and language disorders.
| Product name |
Trofinetide |
| CAS | 853400-76-7 |
| molecular formula | C13H21N3O6 |
| Molecular weight | 315.32 |
| melting point | 144 °C |
| boiling point | 655.4±55.0 °C(Predicted) |
| density | 1.377±0.06 g/cm3(Predicted) |
| Solubility | water (slightly soluble) |
| The acidity coefficient (PKA) | 3.51±0.10(Predicted). |
| Storage condition | Sealed in dry,Room Temperature |
What is the action mechanism of Trofinetide ?
Trofinetide is a synthetic peptide drug with multi-target neuroprotective effect, and its mechanism of action is mainly realized through the following aspects:
Molecular structure and basic mechanism
It is an endogenous synthetic analog, and the unnatural amino acid (S)-2-methylpyrolidine-2-carboxylic acid hydrochloride is used to replace DL-Proline in natural compounds. This structural modification makes it have better pharmacokinetic characteristics.
Multi-target neuroprotection
1. Synaptic function regulation
Trofinetide can enhance synaptic activity, restore synaptic structure, and improve neuron function by increasing dendrite branching and synaptic plasticity signals.
2. Neuroinflammation inhibition
By regulating the signal pathway, it significantly inhibits the neuroinflammatory response. The specific performance is as follows:
Inhibit phosphorylation and down-regulate the release of proinflammatory factors
Significantly reduce the level of inflammatory factors and inhibit the expression of microglia activation marker Iba-1.
3. Inhibition of neuronal apoptosis
It plays an anti-apoptosis role by regulating the expression of apoptosis-related proteins:
4. Pathological regulation of amyloid protein
In the model of Alzheimer's disease, it inhibits β -secretase activity by activating PPAR-γ pathway, thus reducing the production and deposition of Aβ.
5. Antioxidant stress
Trofinetide can increase antioxidant response, reduce oxidative stress damage and protect neurons from oxidative damage.
Signal pathway regulation and molecular docking studies show that it has high binding affinity, which provides a molecular basis for its multi-target effect.
Product Specification
| Items | Specifications | Results |
|
Appearance |
White powder | Complies |
| Assay (HPLC) | 98.0% -102% | 99.26% |
| Water Content | ≤ 0.50% | 0.23% |
|
Heavy Metals |
≤20ppm |
<20ppm |
|
Microbial Limit |
≤20ppm |
<20ppm |
| Yeast &Mold | ≤50cfu/g | <10cfu/g |
| Coliforms | ≤3cfu/g | <3cfu/g |
| E.Coli | Negative/10g | Negative |
| Salmonella | Negative/25g | Negative |
| S.aureus | Negative/25g | Negative |
| Conclusion: The test results are conformed to the in-house specification | ||
How and where to buy Trofinetide wholesale ?
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A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Send your Inquiry for more details , Click email : sales7@faithfulbio.com Now.
FAQ:
Q1:Can you provide samples for quality inspection and experiment?
A1:Of course. We are willing to provide free samples for your evaluation for sincere potential customers. Customers need to bear the international express freight. Please submit a sample application through our business email.
Q2: What is the price?
A2:The price varies according to the quantity ordered, product specifications (purity grade) and packaging requirements. Please let us know your specific requirements and we will provide you with a competitive quotation.
Q3: How do you pack your products?
A3: We use multi-layer sealed packaging to ensure that the products are protected from moisture and deterioration during transportation and storage. The inner layer is sealed with double polyethylene bags. Middle layer: aluminum foil bag. Outer layer: moisture-proof HDPE plastic bucket or cardboard bucket.
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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