What is H-Ala-His-Lys-OH peptide?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. H-Ala-His-Lys-OH peptide, CAS No. 126828-32-8, is a biomimetic tripeptide artificially synthesized from three amino acids: alanine, histidine, and lysine. It appears as a white powder and exhibits excellent water solubility. Its molecular formula is C₁₅H₂₆N₆O₄, and its molecular weight is 354.4. The histidine residue within the molecule possesses an imidazole ring structure, giving the substance outstanding metal chelating ability, enabling it to bind with copper ions to form stable complexes, expanding its application scenarios in the personal care raw material field.
Application of H-Ala-His-Lys-OH peptide
H-Ala-His-Lys-OH peptide, a biomimetic tripeptide-based skincare ingredient, possesses excellent metal chelating properties, allowing it to form stable complexes with copper ions. It is widely used in skin and scalp-related formulations. It can act on skin fibroblasts, assisting in the production of collagen and elastin in the skin matrix, helping to maintain good skin texture. Simultaneously, it can be applied to scalp care products, optimizing the scalp environment and aligning with product development focused on hair follicle care. This ingredient exhibits good compatibility, allowing it to be added to various personal care formulations such as serums, lotions, gels, and shampoos. It can also be modified through palmitoylation to obtain lipid-soluble derivatives, further enhancing its surface penetration performance. It is primarily used in cosmetic formulation research and development and finished product manufacturing.
COA
| Test Item | Specification | Test Result |
| Appearance | White powder | Complies |
| Solubility | Freely soluble in water | Complies |
| Purity(HPLC) | ≥98.0% | 98.65% |
| Water Content(KF) | ≤5.0% | 2.12% |
| TFA Residue | ≤1.0% | 0.35% |
| Single Unknown Impurity | ≤1.0% | 0.41% |
| Tota Impurities | ≤2.0% | 1.35% |
| Heavy Metals(Pb) | ≤10ppm | Complies |
| Heavy Metals(Cd/Hg/As) | Compliant with cosmetic grade standard |
Complies |
| Assay | 95.0%~105.0% | 99.23% |
| Conclusion | Conform with enterprise specification | |
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Molecular Formula: C15H26N6O4
Molecular Weight: 354.4
Exact Mass: 354.20200
PSA: 176.22000
LogP: 0.66500
InChIKey SHKGHIFSEAGTNL-DLOVCJGASA-N
Mechanism of action of H-Ala-His-Lys-OH peptide
Metal ion chelation: The imidazole group of histidine in the molecule can bind to metal ions such as copper to form stable peptide-metal complexes, regulating the local metal ion environment and reducing the negative effects of free metals. This is an important functional basis of the peptide.
Cellular signal regulation: H-Ala-His-Lys-OH Peptide as a biomimetic signal peptide, it acts on skin fibroblasts to transmit biological signals, promote the synthesis of matrix components such as collagen and elastin, and maintain the integrity of the skin matrix structure.
Matrix component homeostasis maintenance: Helps balance matrix-related metabolic activities within the skin, maintains normal levels of extracellular matrix components, and contributes to maintaining a smooth and plump skin appearance.
Scalp microenvironment regulation: Acts on the scalp, regulates local scalp conditions, creates a suitable environment for the scalp and hair follicles, and supports the development of scalp care formulations.
Improved penetration efficiency after modification: Palmitoylation modification yields lipophilic derivatives, which improve molecular lipophilicity, making it easier to penetrate the skin surface barrier and amplify the performance of peptides in the formulation.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. Are there any common derivatives of H-Ala-His-Lys-OH?
Yes, palmitoylation yields PalmitoylTripeptide-28, which has increased lipid solubility and facilitates penetration of the skin barrier.
02. What are the storage requirements for H-Ala-His-Lys-OH?
Store the solid powder sealed at -20°C; it can withstand short-term transportation at room temperature.
03. Can H-Ala-His-Lys-OH be used directly as a finished product?
No, H-Ala-His-Lys-OH peptide is a raw material used only for formulation and cannot be applied directly to the skin. It needs to be incorporated into cosmetic systems.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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