What is FOXO4-DRI?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. FOXO4-DRI, CAS No. 2460055-10-9, is a retro-inverso all-D amino acid synthetic polypeptide. It appears as a white to off-white powder, with a purity exceeding 98% as determined by mainstream HPLC. This polypeptide consists of 44 D-amino acid units, possesses cell-penetrating properties, and can competitively intervene in the protein-protein interaction between FOXO4 and p53, interfering with their protein-protein binding process. It is a highly sought-after research tool in cell biology.
Application of FOXO4-DRI
FOXO4-DRI (CAS 2460055-10-9), a classic research peptide tool, is mainly used in the study of basic mechanisms related to cellular senescence. It is often used in in vitro cell models and animal experimental systems to investigate the behavior of senescent cells, the regulation of cell homeostasis, and changes in the tissue microenvironment by intervening in the protein-protein interaction between FOXO4 and p53. It can also be used for molecular biology experiments such as verifying protein-protein interaction mechanisms and evaluating peptide functional activity. It is often used for the construction of materials and academic models in related research projects, providing experimental materials for the exploration of mechanisms related to senescence.
COA
| Test Item | Specification | Test Result |
| Appearance | White to off-white powder | White to off-white powder |
| HPLC Identity | Conforms | Conforms |
| MS Identity (Mass Spectrum) | Consistent with theoretical mass | Consistent |
| Purity(HPLC) | ≥98.0% | 99.21% |
| Water Content(Karl-Fischer) | ≤8.0% | 4.35% |
| Acetic Acid Residue | ≤1.0% | 0.32% |
| TFA Residue | ≤0.5% | 0.18% |
| Solubility | Soluble in water and DMSO | Complies |
| pH(1mg/mL aqueous solution) | 5.0-7.5 | 6.23 |
| Residual Organic Solvents | Meet ICH requirements | Complies |
| Heavy Metals(Pb,Cd,Hg,As) | ≤10 ppm | Complies |
| Peptide Content | ≥95.0% | 96.40% |
| Conclusion | Conform with enterprise specification | |
Click email：sales4@faithfulbio.com Or WhatsApp：+86 17782784907
FOXO4-DRI, as a retro-inverso tool for synthesizing peptides from all D-amino acids, is currently used in two main experimental directions: in vitro cell experiments and animal model experiments. Its core mechanism is to competitively interfere with the protein binding of FOXO4 and p53, causing p53 to migrate outside the nucleus, thereby regulating the survival status of senescent cells, while having little effect on normal proliferating cells.
Mechanism of action of FOXO4-DRI
Targeted protein interaction interference: Belongs to the retro-inverso all-D amino acid polypeptide, it competitively binds to p53 protein, blocking the interaction between endogenous FOXO4 protein and p53.
Altering p53 intracellular localization: Disrupts the anchoring binding of FOXO4 to p53, promoting the translocation of p53 from the nucleus to the cytoplasm, thus altering the intracellular distribution of p53.
Regulating the survival balance of senescent cells: In senescent cells, the aforementioned protein repositioning alters cell survival-related signals, selectively changing the survival status of senescent cells with minimal impact on normal cells.
Downregulating senescence-related molecular markers: Reducing the expression of senescence markers such as p16, p21, and γ-H2AX, weakening the release of senescence-related secreted phenotypic factors, and improving the cellular microenvironment.
Structure leading to protease resistance: Constructed entirely of D-configuration amino acids, it is not easily degraded by common proteases, enhancing the stability of the peptide in experimental systems and enabling cell penetration to exert its effects.
why choose us
We adhere to the principle of "customer first, honesty first", and always provide customers with high-quality and efficient products and high-quality services. Choose faithfulness. Choose a healthy life!
With our continuous efforts and good service, we sincerely hope to establish long-term cooperation and common development with customers and give us a chance. We believe that we will satisfy you with first-class quality, safe and fast delivery and enthusiastic after-sales service.
Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. In which experiments is FOXO4-DRI primarily used?
FOXO4-DRI is used to study the fundamental mechanisms of cellular senescence, conducting in vitro cell and animal model experiments. It can be used for protein-protein interaction verification, cell homeostasis, tissue microenvironment, and fibrosis-related research.
02. What is the typical in vitro concentration range for FOXO4-DRI?
The commonly used working concentration for in vitro cell experiments is 5-25 μM, with a treatment time of 24-72 hours. Conditions can be optimized based on different cell models.
03. Does FOXO4-DRI have a significant effect on normal cells?
Current research data shows that FOXO4-DRI has a relatively small effect on normally proliferating cells, primarily regulating senescent cells.
Click email：Sales4@Faithfulbio.Com Or WhatsApp：+86 17782784907
Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
Hot Tags: foxo4-dri cas 2460055-10-9, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China