FGL Peptide CAS 499993-62-3

Application of FGL peptide

Both in vitro cell culture and animal model observations have revealed that the FGL peptide can promote the outward extension of neuronal processes, aiding in the generation and remodeling of synaptic structures between neurons. Simultaneously, it can mobilize progenitor neural stem cells in the hippocampus to proliferate and differentiate, enriching the number of newly generated neurons in the brain. It can also act on glial cells in the brain, balancing their activity and regulating the release levels of various signaling factors, creating a stable microenvironment for neuronal survival. Related observational data show that this peptide possesses the ability to cross the blood-brain barrier, directly reaching brain regions such as the hippocampus related to learning and spatial memory, continuously optimizing the plasticity of neural circuits. It is a commonly used active peptide tool molecule in the field of basic neuroscience research, but current exploration is only at the basic experimental stage at the cellular and animal levels.

FGL peptide has a precise molecular weight of 1659.85 Da. The molecule contains basic amino acids such as lysine, and its overall isoelectric point (pI) is approximately 9.52. Under neutral aqueous conditions, the molecule carries a positive charge. The peptide side chains are rich in hydrophilic polar groups, exhibiting excellent solubility in pure water and neutral buffer solutions at room temperature, with little tendency to precipitate or form a solid white powder. It is structurally stable and can retain its original molecular structure and biocombining activity for a long time under normal light-protected and low-temperature storage conditions. However, prolonged exposure to high temperatures, strong light, or strong acid/alkali environments can easily cause peptide chain breakage and amino acid residue denaturation, leading to the loss of its original functional properties.