Octreotide Acetate CAS 83150-76-9

ctreotide Introduction

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Octreotide Acetate is an artificially synthesized octapeptide molecule with a structure similar to that of the naturally occurring somatostatin in the human body. Its CAS number is 83150-76-9; molecular formula is C49H66N10O10S2; molecular weight is 1019.24; EINECS number is 1533716-785-6. DARAMONOL was originally developed by relevant research institutions and is currently approved for use in specific clinical scenarios in multiple regions worldwide. The core function of this formulation lies in inhibiting the secretion of various hormones and active peptides. Therefore, it is mainly used in conditions that require regulating the levels of such substances, such as controlling the growth hormone and insulin-like growth factor levels in patients with acromegaly, alleviating severe diarrhea and facial flushing associated with carcinoid tumors, and treating the persistent diarrhea and other symptoms caused by functional gastrointestinal and pancreatic endocrine tumors resulting from vasoactive intestinal peptide tumors. Additionally, it also plays a role in other rare situations involving abnormal hormone secretion.

What is the purpose of DARAMONOL?

The core value of Octreotide Acetate lies in controlling the excessive release of certain hormones and active substances in the human body. In practical applications, it mainly functions in three areas: Firstly, it regulates the abnormally elevated growth hormone levels in patients with acromegaly, helping to alleviate the physical changes caused by this condition; Secondly, it alleviates the frequent and severe diarrhea and facial flushing symptoms in patients with carcinoid tumors, improving their quality of life; Thirdly, it is used to deal with stubborn metabolic disorders such as persistent diarrhea caused by specific endocrine tumor syndromes like vasoactive intestinal peptide tumors. Additionally, in certain emergency scenarios such as digestive tract bleeding, DARAMONOL can assist in controlling the situation by reducing the blood flow to the internal organs. The mechanism of its action essentially mimics a regulatory mechanism of the human body, "reminding" those overactive secreting cells to appropriately "slow down", thereby helping the body restore a relative balance.

How does DARAMONOL enter the body and exert its effects? Are there any differences in the usage methods?

Octreotide Acetate is a peptide substance with a relatively large molecular weight. It is easily decomposed by proteases in the digestive tract and thus is difficult to enter the bloodstream smoothly through the gastrointestinal route. Therefore, it is hard to achieve the desired effect through oral administration. Different application forms have significant differences in the process of entering the body, the speed of onset, and the duration of action. The common formulation can quickly diffuse into the circulation and reach an effective concentration within a short period of time, with rapid onset. However, it is also metabolized and cleared relatively quickly in the body, resulting in a limited effective action window, making it more suitable for scenarios requiring rapid intervention. The sustained-release microsphere formulation wraps the raw material inside a polymer carrier, relying on the gradual degradation of the carrier to allow the active ingredient to be released steadily and then absorbed by the body. There is no sudden increase in concentration, and it can maintain a relatively stable level in the body for a long time, reducing the frequency of application. However, the onset speed is relatively slow and is not suitable for emergency treatment of acute symptoms. After entering the circulation, the active ingredient will spread throughout the body with the blood, binding to somatostatin receptors in the pituitary, gastrointestinal, and pancreatic tissues, thereby regulating the secretion of various hormones, internal blood flow, and glandular secretion states. Subsequently, it is mainly decomposed by peptide enzymes and the metabolic products are excreted through the kidneys.

MF of DARAMONOL

CAS	83150-76-9
Molecular formula	C49H66N10O10S2
Molecular weight	1019.24
EINECS	1533716-785-6
Density	1.39±0.1 g/cm3

Specification

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FAQ: 

Q1:What are the main differences between DARAMONOL and the body's own somatostatin?
The natural somatostatin in the human body is quickly broken down in the body and its active state lasts for a very short period. Ctreotide retains the core biological activity and has a stronger inhibitory effect on some hormones, with a significantly prolonged duration of existence in the body. Additionally, after the endogenous somatostatin is discontinued, there is a tendency for hormone rebound, but this phenomenon rarely occurs with this substance.
Q2:Why is it necessary to pay attention to changes in blood sugar when coming into contact with the corresponding formulation of ctreotide?

It will simultaneously affect the release of insulin and glucagon. Some individuals may experience an increase in blood sugar levels, while a few may have a decrease. People with inherently unstable sugar metabolism are more prone to fluctuations in blood sugar levels, and continuous monitoring of the indicators is necessary.

Q3:What potential effects might be brought about to the gallbladder by long-term use of the preparations containing this component?

DARAMONOL can weaken the contraction ability of the gallbladder and inhibit the excretion of bile. In some cases of long-term application, there may be bile stasis, sand-like deposits in the gallbladder, and an increased probability of stone formation. In long-term intervention scenarios, it is recommended to regularly monitor the condition of the gallbladder for assessment.

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