Flagelin 22 TFA CAS 304642-91-9

Flagelin 22 TFA CAS 304642-91-9 (flg22 for short) is a synthetic polypeptide composed of 22 amino acids, derived from the highly conserved N-terminal region of bacterial flagellin. Its amino acid sequence is QRLSTGSRINSAKDDAAGLQIA, its molecular formula is C₉₃H₁₆₂N₃₂O₃₄, and its molecular weight is 2272.48. It is a white to off-white solid and is stable at -20°C. As a potent elicitor of plant innate immunity, it is specifically recognized by the pattern recognition receptor FLS2 and its co-receptor BAK1 on the plant cell surface. Upon binding, it triggers a conformational change in the receptor and forms a complex, which in turn activates the downstream MAP kinase signaling pathway, triggering reactive oxygen species bursts, calcium ion influx, and the expression of defense genes. Ultimately, this induces defensive responses in plants, such as hypersensitivity reactions, cell wall strengthening, and the synthesis of antimicrobial substances, thereby enhancing plant resistance to pathogens.

Currently, flg22 is not only an important research tool in the study of plant immune signaling pathways, pathogen recognition mechanisms and cross-species defense responses, but also has potential agricultural application value. It can be used as a biological inducer to stimulate broad-spectrum disease resistance in crops, reduce dependence on chemical agents, and effectively induce immune responses in model plants such as Arabidopsis thaliana and tomato, as well as algae.

Application Value

Research Tool: Used for research on plant immune signaling pathways, pathogen recognition mechanisms, and cross-species defense responses.

Agricultural Potential: Can be used as a biological inducer to stimulate broad-spectrum disease resistance in crops, reducing reliance on chemical agents.

Model Organism: Can induce immune responses in model plants such as Arabidopsis thaliana and tomato, as well as algae.