Semaglutide 99% White Powder CAS 910463-68-2
Product Name:Semaglutide
Synonym:Sermaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;Sermaglutide CAS 910463 68 2;Semaglutide (H-7894.0001);semgalutide
CAS NO.:910463-68-2
EINECS NO.:203-405-2
Molecular Formula:C187H291N45O59
Purity & Grade: 99%; Medicine grade
Character:White powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 100mg; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 5-10 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description
Semaglutide 99% White Powder CAS 910463-68-2 is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) that is widely used in diabetes management and obesity treatment due to its multiple effects of lowering blood sugar, weight loss and cardiovascular benefits.
GLP-1, scientifically known as glucagon-like peptide-1, is a gut-brain peptide secreted by ileal endocrine cells.
When GLP-1 binds to its receptor, it stimulates insulin secretion and inhibits glucagon release, thereby lowering blood sugar.
This process involves another important chemical, dipeptidyl enzyme-4, commonly known as DPP-4. The main function of DPP-4 is to degrade GLP-1 in the body, maintaining a balance of GLP-1 levels.
Studies have found that type 2 diabetes patients commonly experience insufficient GLP-1 secretion. The already insufficient GLP-1 is further weakened by the degradation effect of DPP-4, leading to elevated blood sugar levels. Therefore, the main approaches to lowering blood sugar include two aspects: one is to develop DPP-4 inhibitors to inactivate DPP-4; the other is to develop biosimilars of GLP-1 to compensate for GLP-1 deficiency.
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COA
| Tests | Specifications | Results |
| Appearance | White or almost white fluffy powder | Conform |
| Solubility | Soluble in water | Conform |
| Water Content (Karl Fischer) | ≤ 8.0% | 4.80% |
| Sodium ion | ≤ 5.0% | 2.10% |
| Trifluoroacetic Acid | ≤ 0.5% | Not Detected |
| Peptide Purity (By HPLC) | ≥ 98.0% | 99.82% |
| Related Substance | Total Impurities(%) ≤ 2.0% | 0.18% |
| (By HPLC) | ||
| Largest Single Impurity(%) ≤ 1.0% | 0.13% | |
| Bacterial | ≤10EU/mg | Conform |
| Endotoxins | ||
| Total Aerobic Microbial Count | ≤10² cfu/g | Conform |
| Total Yeast And Mold Count | ≤10² cfu/g | Conform |
| Assay | 95.0 ~ 105.0% | 101.54% |
| Residual Solvents | Acetonitrile:NMT 410ppm | 138ppm |
| Dichloromethane:NMT 600ppm | Not Detected | |
| DMF:NMT 880ppm | Not Detected | |
| Conclusion | Conform with enterprise specification | |
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Semaglutide is very similar to natural GLP-1, with only two structural differences: (1) the alanine amino acid at position 8 is replaced by α-aminoisobutyric acid, which makes the molecule more resistant to DPP-4 degradation; (2) the introduced longer carbon chain and flexible fatty chain conjugates C18 fatty acid diacid to lysine at position 26, thereby improving its albumin binding properties, which prolongs the product's lifespan in plasma and reduces its renal clearance.
Mechanism of Action of Semaglutide 99% White Powder CAS 910463-68-2
Semaglutide achieves multiple physiological effects by mimicking the function of the body's natural incretin GLP-1:
Hypoglycemic effect: When blood glucose is elevated, it specifically activates GLP-1 receptors on pancreatic β cells, promoting insulin secretion; simultaneously, it inhibits glucagon secretion from pancreatic α cells, reducing hepatic glucose output, thus bidirectionally regulating blood glucose levels with a low risk of hypoglycemia.
Weight loss effect: It slows gastric emptying, prolongs the feeling of fullness, and reduces food intake; it also regulates the hypothalamic appetite center, reducing appetite drive, thereby aiding in weight loss.
Cardiovascular protective effect: It can improve vascular endothelial function, lower blood pressure, reduce inflammatory responses, and significantly reduce the risk of major adverse cardiovascular events (such as myocardial infarction, stroke, and cardiovascular death) in patients with type 2 diabetes and cardiovascular disease.
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Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ
01. How does Semaglutide 99% White Powder CAS 910463-68-2 work?
02. What are the common side effects of Semaglutide 99% White Powder CAS 910463-68-2?
Common side effects are usually mild and include nausea, vomiting, diarrhea, constipation, abdominal pain, heartburn, and belching. These symptoms usually subside as the body adapts.
03. Where can I buy Semaglutide 99% White Powder CAS 910463-68-2?
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