what is MSA-2?
MSA-2 is a kind of light yellow powder.It is an available non-nucleotide STING agonist used in cancer research, known for its ability to stimulate an anti-tumor immune response by activating the STING pathway, inducing interferon-beta (IFN-β) secretion, promoting tumor regression, and synergizing with other immunotherapies like anti-PD-1 antibodies.
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Product name |
MSA-2 |
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CAS |
129425-81-6 |
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Molecular formula |
C14H14O5S | |
| EINECS | 207-048-3 | |
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Molecular weight |
294.32 | |
| Melting point | 509.3±50.0°C(Predicted) | |
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Appearance |
light yellow powder |
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| Density | 1.336±0.06g/cm3(Predicted) |
What is main applicatons of MSA-2?
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Its primary application is in cancer immunotherapy, aiming to harness the immune system to fight tumors.
MSA-2 shows particular promise when combined with other cancer treatments, such as anti-PD-1 therapy, to overcome resistance and enhance efficacy.
Its unique structural traits provide avenues for further modifications and the development of targeted delivery systems for future research and clinical applications. |
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If you need it, pls click e-mailsales1@faithfulbio.com |
Product Specification
| Items | Specifications |
Result |
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Appearance |
light yellow powder |
Conforms |
| Identification | Positive | Conforms |
| Loss on Drying |
5% MAX |
0.26% |
| Residue on Burning | 5% MAX | 0.57% |
| Heavy metals | 10ppm MAX |
<10ppm |
| Purity | 98% MIN | 98.5% |
How MSA-2 works ?
Activates STING:
MSA-2 binds to the STING (Stimulator of Interferon Genes) protein, initiating a downstream cascade of immune signals.
Induces IFN-β:
This activation leads to the secretion of interferon-beta (IFN-β), an inflammatory cytokine that plays a role in anti-tumor immunity.
Promotes antitumor activity:
By stimulating the immune system, MSA-2 can inhibit tumor growth, induce complete tumor regression, and establish durable antitumor immunity.
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In cell-free assays, MSA-2 can bind to STING in both humans and mice. MSA-2 exhibited similar oral and subcutaneous exposure in mice. In tumor bearing mice, MSA-2 induces an increase in beta interferon in plasma and tumor through two administration routes. The well tolerated MSA-2 course induced tumor regression in mice carrying MC38 syngeneictumor. Most mice that showed complete regression were resistant to re inoculation of MC38 cells, indicating the establishment of a persistent anti-tumor immune response. In tumor models with moderate or poor response to PD-1 blockade, the combination of MSA-2 and anti-PD-1 antibodies is superior to monotherapy in inhibiting tumor growth and prolonging survival. |
How and where to buy MSA-2?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q:Can I just buy 100mg MSA-2?
A: Of course, we can provide you 100mg MSA-2 raw powder.
Q: What is your cash-on-delivery policy?
A: Unfortunately, we currently do not support cash on delivery. You can make payment through bank transfer or other methods.
Q: How do you ensure the quality of your products?
A: Our products are strictly controlled at every stage of the production process to ensure consistency in purity and quality. You can also go to a third-party testing agency for testing after receiving the goods.
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
Send your Inquiry for more details, Click email：sales1@faithfulbio.com Now.
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