what is Eptifibatide peptide?
Eptifibatide peptide (CAS 148031-34-9) is a white to off white powder. MF:C₃₅H₄₉N₁₁O₉S₂,MW831.96. It is an artificially synthesized cyclic heptapeptide, inspired by a protein in the venom of the Southeastern dwarf rattlesnake in the United States. As a glycoprotein IIb/IIIa receptor antagonist, Eptifibatide can effectively inhibit platelet aggregation through reversible competitive binding. Epifibatide is mainly used to treat acute coronary syndrome (such as unstable angina and non ST segment elevation myocardial infarction), especially for patients planning to undergo percutaneous coronary intervention (PCI) to reduce the risk of death or new myocardial infarction. As a peptide anticoagulant raw material, it has a wide range of applications in the cardiovascular field.
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Product name |
Eptifibatide peptide |
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CAS |
188627-80-7 | |
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Molecular formula |
C35H49N11O9S2 |
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| EINECS | 641-366-7 | |
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Molecular weight |
831.97 | |
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Appearance |
white powder |
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| Storage | Sealed in dry,Store in freezer, under -20°C | |
| Density | 1.60±0.1 g/cm3(Predicted) |
What are uses of Eptifibatide peptide?
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Eptifibatide peptide is used to reduce the risk of acute cardiac ischemic events (death and/or myocardial infarction) in patients with unstable angina or non-ST-segment-elevation (e.g., non-Q-wave) myocardial infarction (i.e., non-ST-segment elevation acute coronary syndromes) both in patients who are to receive non surgery (conservative) medical treatment and those undergoing percutaneous coronary intervention (PCI). |
Product Specification
| Items | Specifications |
Result |
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Appearance |
White powder |
Conforms |
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Solubility |
Very soluble in water (＞1mg/ml) |
Conforms |
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Identification by HPLC |
Retention time is same with the reference substance |
Conforms |
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Molecular Ion Mass |
931.96±1 |
Conforms |
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Specific optical rotation |
-75°~ -95°(c=1%, HAc) |
Conforms |
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Amino acid composition |
±20% |
Conforms |
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Purity(HPLC) |
98.0%min |
99.1% |
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Related substances(HPLC) |
Total impurities ＜2.0% Single impurity ＜1.0% |
0.9% 0.5% |
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Acetic acid (HPLC) |
≤12.0% |
8.7% |
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Water content(Karl Fischer) |
≤6.0% |
4.6% |
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Peptide content |
80.0% min |
86.5% |
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Residual solvents (Acetonitrile) |
≤0.041% |
Conforms |
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Bacterial endotoxins |
≤5EU/mg |
Conforms |
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Assay (by Anhydrous, Acetic Acid-free) |
95.0~105.0% |
Conforms |
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what is the mechenism of action of Eptifibatide peptide?
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Eptifibatide peptide has a modified amino acid chain of lysine glycine aspartic acid, which can bind to GP IIb/IIIa receptors and block GP IIb/IIIa receptors, thereby preventing coagulation factor I from binding to platelet GP IIb/IIIa receptors and exerting antiplatelet aggregation effects. The inhibitory effect of Eptifibatide peptide on GP IIb/IIIa receptors is competitive inhibition, and the inhibitory effect is concentration dependent. In addition, the binding of eptifibatide to GP IIb/IIIa receptors is reversible, and the effect is reduced by half 4 hours after discontinuation. The drug efficacy can be rapidly reversed with the termination of administration, and treatment does not increase the risk of bleeding. And studies have shown that administration of eptipatide did not detect serum antibodies or immune reactions. |
what is the side affects of Eptifibatide peptide?
People receiving Eptifibatide peptide are typically seriously ill and most of them are concomitantly treated with other drugs known to have the potential to cause significant side effects. Therefore, not all side effects listed as follows may be attributable to Eptifibatide treatment alone:
The major adverse event was severe bleeding. Bleeding occurred as well at sites of clinical intervention (local sites) as at other sites (systemically) like urogenital bleeds. Sometimes, these events were severe enough to require transfusion of blood or plasma concentrates to stop bleeding and counteract anemia.
Additionally, hypotension was seen frequently (6%). Cardiovascular failure was also frequent (2%) as were serious arrhythmias (ventricular fibrillation 1.5%, atrial fibrillation 6%). Severe allergic (anaphylactic) reactions occurred in almost 0.2% of patients.
Company profile
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q1:What are the advantages of Epifibatide compared to Abciximab?
A1:Compared to Abciximab, Eptifibatide has stronger, more targeted, and specific binding to GP IIb/IIIa due to the presence of a single conserved amino acid substitution - lysine replacing arginine.
Q2:What is the mechanism of action of eptifibatide?
A2:Eptifibatide reversibly inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive ligands to GP IIb/IIIa. When administered intravenously, eptifibatide inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner.
Q3:what is the MOQ of the order?
A3:Moq of Eptifibatide is 1g .
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