Matrixyl CAS 214047-00-4

SYN-AKE Introduction

Peptides play an important role in the natural aging and care of the skin, such as cell proliferation, cell migration, inflammation, angiogenesis, pigment formation, and protein synthesis and regulation. Matrixyl powder, a white to off white solid, stands out among these peptides.CAS Number: 214047-00-4. Molecular formula: C39H75N7O10; Molecular weight: 802.06; EINECS Number: 606-757-9. According to a survey, the most frequently used peptides by well-known domestic and foreign brands are palmitoyl pentapeptide-3 (Pentapeptide-4), acetyl hexapeptide-3, acetyl tetrapeptide-5, palmitoyl oligopeptide (palmitoyl tripeptide-1), palmitoyl tetrapeptide-3, and L-Carnosine, and so on. Among them, the search results for 214047-00-4 Palmitoyl Pentapeptide-4 used by various brands show over 1000, far higher than other similar peptide products, indicating its wide application.

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What are the functions of Palmitoyl Pentapeptide?

Palmitoyl Pentapeptide is a naturally active short peptide derived from the human body, consisting of five amino acid chains. It has a compact structure that is different from the large-molecule proteins composed of hundreds of amino acids. It can simulate the mechanism of botulinum toxin and also serves as a classic skin signaling peptide. It can replicate the KTTKS active fragment of human type I procollagen and transmit repair and regeneration signals to skin fibroblasts. It efficiently promotes the production of type I and type III collagen, elastin, and hyaluronic acid, strengthens the skin support from the dermal layer, tightens the skin, and reduces fine lines and wrinkles. Unlike most skin care ingredients that only remain on the surface, this low-molecular short peptide has a stable structure and excellent permeability. It can smoothly penetrate the skin's stratum corneum and reach the dermal layer, effectively increasing skin moisture content, thickening the skin texture, and improving dryness and sagging. At an appropriate concentration, Matrixyl can regulate CTGF (connective tissue growth factor) and guide skin health repair, reducing the tendency of scar formation. Its unique short peptide amino acid structure is stable and will not experience efficacy loss or excessive absorption problems. Combined with its own palmitoyl lipid-soluble structure, it further enhances the transdermal efficiency. Clinical tests have shown that at a low dose, it can effectively improve the aging state of the skin for a long time.

What is the application of Palmitoyl Pentapeptide in toothpaste?

Pharmaceutical grade Matrixyl powder is actually the C‑terminal fragment of collagen I, delivering effects comparable to laser surgery. Moderate amounts of this ingredient are commonly incorporated into certain therapeutic toothpastes for daily‑use. It works like performing mild micro‑repair similar to mini‑laser treatment inside the oral cavity to indirectly repair micro‑damage of human oral mucosa. Unlike laser surgery, long‑term application of pentapeptide enables close interaction with tissues, modulates skin ecology and cellular repair processes, so as to prevent and ameliorate gingival atrophy. It functions in a manner analogous to intracellular hormones and enzymes.

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FAQ:

Q1:What is the typical concentration of its addition in the formula?
As an active ingredient, its addition concentration is usually within the range of 100 ppm to 500 ppm (i.e. 0.01% - 0.05%). Even at such a low concentration, it has shown clear anti-wrinkle effects in clinical trials.
Q2:Does the mechanism of action of Palmitoyl Pentapeptide lead to excessive skin proliferation or scarring?

It requires precise regulation. The research indicates that the KTTKS fragment has both the characteristics of promoting repair and possibly promoting fibrosis. At a specific concentration of 0.1 µM, it can inhibit the formation of myofibroblasts, but at a higher concentration (0.5 µM), the effect is not significant. This reminds us that in product design, the balance between its repair and fibrotic-promoting effects needs to be considered.

Q3:Apart from anti-wrinkle effects, does it have any role in wound healing as well?

Some basic research has shown that it plays a role in the wound healing process, influencing the expression of α-smooth muscle actin (α-SMA) and connective tissue growth factor, which is related to the scarring process. However, this is mainly an in vitro cell-level study and does not directly equate to skincare efficacy.

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