Is efavirenz antiviral?
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TENOFOVIR (te NOE fo veer) is an antiretroviral medicine. It is used with other medicines to treat hepatitis B virus and HIV. This medicine is not a cure for hepatitis B or HIV. This medicine can lower, but not fully prevent, the risk of spreading hepatitis B or HIV to others.
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What type of drug is efavirenz?
Efavirenz is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood.
What is the mechanism of action of efavirenz?
Similar to zidovudine, efavirenz inhibits the activity of viral RNA-directed DNA polymerase (i.e., reverse transcriptase). Antiviral activity of efavirenz is dependent on intracellular conversion to the active triphosphorylated form. The rate of efavirenz phosphorylation varies, depending on cell type.
Is efavirenz still used?
Efavirenz is an antiretroviral medication used to treat and prevent HIV/AIDS. It is generally recommended for use with other antiretrovirals.
What are the benefits of efavirenz?
It works by lowering the amount of HIV in the blood and helps the immune system. This may help delay some of the medical conditions that usually result from AIDS or HIV disease. It will not keep you from spreading HIV to other people.
Is efavirenz FDA approved?
Efavirenz is an FDA-approved antiretroviral medication introduced in 1998 (and approved for use in the UE in 1999) that has played a pivotal role in the treatment and prevention of HIV.
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Common side effects of efavirenz may include:
Rash; headache, tired feeling; sleep problems (insomnia), strange dreams; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
The neuropsychiatric side effects of efavirenz usually begin quickly, commonly peak in the first two weeks after the start of therapy, and can include depression, anxiety, sleep disturbances, impaired concentration, aggressive behavior, paranoia, psychosis.
Is efavirenz toxic?
Efavirenz usually causes early neuropsychiatric toxicity, which is usually not severe enough to warrant discontinuation, and usually resolves on its own even with continued use of efavirenz.
Is efavirenz nephrotoxic?
Although this case suggests a need for increased vigilance and further studies, the authors have not established a causal relationship between efavirenz and the development of glomerular disease in their patient.
How does efavirenz work?
It blocks the activity of reverse transcriptase, an enzyme produced by HIV that can infect cells in the body and make more virus. By blocking this enzyme, Efavirenz, in combination with other antiviral drugs, reduces the amount of HIV in the blood and keeps it low.
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