Raw Materials Doxepin Hydrochloride CAS 1229-29-4

DOXEPIN is a product used to treat depression and anxiety neurosis. Its function is to inhibit the central nervous system's reuptake of serotonin and norepinephrine, thereby increasing the concentration of these two neurotransmitters in the synaptic cleft and exerting antidepressant effects. In addition, this product also has anti anxiety and sedative effects. The mixture of cis and trans isomers of Doxepin is an oily liquid. If made into Raw Materials Doxepin Hydrochloride, it is a white to off white powder. If not used for a long time, it needs to be stored properly in a -20 ° C refrigerator.

What are the pharmacological effects of this product?

Doxepin is a tricyclic antidepressant product that can inhibit the reuptake of serotonin and norepinephrine, while neglecting the reuptake of dopamine. Clinical studies have found that Doxepin powder has antagonistic effects on various receptors, including H1, H2, 5-HT1, 5-HT2, α 1-adrenergic receptors, and cholinergic receptors. Its potency in blocking H1 receptors is several tens of times higher than that of conventional similar products. In the mouse experimental model, this product has a significant inhibitory effect on systemic itching caused by Dextran in mice, and a significant reduction in skin vascular permeability in mice, which is more effective than conventional products. Raw Materials Doxepin Hydrochloride can also inhibit allergic reactions in guinea pigs caused by histamine phosphate, and its anti allergic effects on three allergy models show a good dose-response relationship.

Is this product a hormone? Can psoriasis be treated?

Raw materials doxepin hydrochloride can be made into topical ointment for the treatment of chronic simple lichen, eczema, allergic dermatitis, atopic dermatitis, etc. We know that long-term use of hormone ointment will have serious side effects, such as pigmentation on the skin surface and abnormal growth of local hair. However, this product is not a hormone product, but an antihistamine product, so you can rest assured and use it for a long time. Local application of this product can improve some allergic diseases or pruritic diseases. However, it is precisely because this product only has the receptor to antagonize histamine in local skin, so it can inhibit histamine, so it can not achieve good therapeutic effect on psoriasis, and hormone ointment should be preferred.

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