L-Tert-leucine amide HCl Introduction
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L-tert-leucinaMide hydrochloride is a chiral amino acid derivative raw material, with the molecular formula C6H15ClN2O and a molecular weight of 166.65. When in the form of a salt, it can significantly improve the water solubility of the raw material and is more stable during storage.
The L-Tert-leucine amide HCl available on the market is mainly produced through a total chemical synthesis process. Generally, L-tert-Leucine is selected as the starting material, and the three steps of amino group protection, amide structure construction, and deprotection purification are completed sequentially to obtain the final product.
L-Tert-leucine amide HCl is only supplied for laboratory research scenarios and is a basic building block commonly used in peptide synthesis. It is mainly used in PEPTIDASE-related activity tests. The N,N-BIS(HYDROXYMETHYL)-TERTBUTYLAMINE in the molecular structure has an extremely large spatial steric hindrance and can act as an efficient chiral auxiliary agent in asymmetric organic synthesis, significantly improving the stereospecificity of the reaction. There is a high demand for it in university laboratories and pharmaceutical company R&D departments.
What is the mechanism of action of L-Tert-leucine amide HCl?
The reactivity of L-tert-leucinaMide hydrochloride mainly stems from the amide functional group within the molecule, as well as the highly steric hindrance of the N,N-BIS(HYDROXYMETHYL)-TERTBUTYLAMINE side chain structure.
L-Tert-leucine amide HCl can form amide bonds with various L-tert-Leucine and chemical groups, constructing custom polypeptides and peptide-like substrates. Researchers will use these substrates to test the recognition and decomposition capabilities of peptide enzymes for different peptide sequence segments.
In addition, the N,N-BIS(HYDROXYMETHYL)-TERTBUTYLAMINE within the molecule can produce a special stereoscopic effect, which can be used as a chiral auxiliary agent in asymmetric synthesis reactions. By relying on spatial steric hindrance to constrain the reaction direction, it can easily obtain highly stereospecific target products.
In summary, this raw material does not interact with intracellular enzymes or receptors to regulate biological signaling pathways and does not belong to bioactive ligands; fundamentally, it is an organic synthesis and chiral molecule-based specialized tool intermediate that only functions in chemical synthesis and molecular construction processes.
What are the advantages of preparing L-Tert-leucine amide in its hydrochloride form?
The pure free amine forms are mostly oily liquids or low-melting-point solids, with high chemical activity. They are prone to oxidation and deterioration during storage, and have poor water solubility, making it difficult to conduct experiments in aqueous buffer systems such as those used in peptide synthesis and asymmetric synthesis.
When ButanaMide, 2-amino-3,3-dimethyl- (2S)-ButanaMide, 2-amino-3,3-dimethyl- (2S)- combines with hydrochloric acid to form a salt, the amino group undergoes protonation, forming stable ionic crystals. On one hand, the water solubility is significantly improved, making it easier to prepare standard reaction solutions and operate the feeding process; on the other hand, the antioxidant performance is significantly enhanced, and the product is a white crystalline powder that is not prone to deterioration over a long period of storage. The crystalline form can also be purified through recrystallization techniques to obtain high-purity materials easily. This is the advantage of L-tert-leucinaMide hydrochloride.
MF of L-Tert-leucine amide HCl
| CAS | 75158-12-2 |
| Molecular formula | C6H15ClN2O |
| Molecular weight | 166.65 |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Assay | ≥98.0% | 99.46% |
| Conclusion | Conform with enterprise specification | |
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FAQ:
Q1:What are the distinctive features of the side chain of L-Tert-leucine amide HCl, namely, N-BIS(HYDROXYMETHYL)-TERTBUTYLAMINE?
It has a large volume and can provide a strong spatial steric effect, thereby controlling the stereoselectivity of molecules in the reaction.
Q2:Is it the same thing as L-Leucinamide hydrochloride?
No. There are significant differences in the side chains, molecular formulas, properties and applications between the two.
Q3:What does "chiral catalyst" mean?
It is akin to a "chiral mold", utilizing the large volume spatial restraints of its N,N-BIS(HYDROXYMETHYL)-TERTBUTYLAMINE to direct the chemical reaction to exclusively produce the target chiral product.
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