What is N-Acetyl-L-cysteine ethyl ester?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. N-Acetyl-L-cysteine ethyl ester, CAS No. 59587-09-6, molecular formula C₇H₁₃NO₃S, molecular weight 191.25, mainstream refined products can achieve a purity of 98%~99%. It is a chiral lipophilic derivative obtained by acetylation and ethyl esterification of the cysteine skeleton. Unlike the water-soluble basic N-acetylcysteine raw material, the ethyl ester group in the molecular structure has significantly weakened polarity, which significantly improves oil compatibility and film penetration ability. N-Acetyl-L-cysteine ethyl ester is mostly a white crystalline powder at room temperature, with a density of 1.138 g/cm³ and a boiling point of 337.6℃ at normal pressure. The molecule carries highly active thiol functional groups, possessing excellent free radical neutralizing properties. It can balance the redox state within the system, mitigating oxidative damage caused by external environmental stimuli. When this material comes into contact with biological membrane structures, it rapidly penetrates the lipid layer due to its strong lipophilic properties. Under the action of internal esterases, it gradually decomposes, releasing basic cysteine derivatives. This helps increase the content of glutathione-related reducing components within the system, stabilizing the in vitro cell culture environment and reducing structural damage caused by reactive oxygen species.
Application of N-Acetyl-L-cysteine ethyl ester
Currently, N-Acetyl-L-cysteine ethyl ester has two main application areas: in vitro scientific research experiments and high-end skin care formulation development. In cell culture-related experimental systems, it is often added as an environmental stabilizing component to optimize the reducing atmosphere of the culture system, maintain normal physiological homeostasis of cells, and reduce interference from external peroxides. In the field of skin care raw materials, relying on its excellent lipid-soluble penetration advantages, it is compatible with various oil-based formulations such as ointments and emulsions. It can penetrate the surface lipid structure of the stratum corneum, neutralize environmental free radicals, and soothe surface problems such as dullness and roughness caused by external stimuli. The industrial supply chain is well-developed, providing various specifications from milligram-level laboratory samples to hundreds of kilogram industrial drums. It is a multifunctional reducing active intermediate that is frequently purchased by research institutions and cosmetic raw material manufacturers. Compared with unmodified water-soluble NAC raw materials, it has a wider range of compatibility with formulation systems and higher efficiency in crossing lipid barriers. It is a modified derivative with outstanding comprehensive compatibility among reduced functional raw materials and is widely used in non-medical research and development scenarios such as in vitro biological mechanism exploration and skin care active compounding.
COA
| Test Item | Specification | Test Result |
| Appearance | White powder | Conforms |
| Specification | 99% | Conforms |
| Odor | Characteristic | Conforms |
| Particle size | 100% pass 80 mesh | Conforms |
| Heavy metals | ||
| Total Heavy metals | ≤10ppm | Conforms |
| Microbial | ||
| Total microbacterial count | ≤1000cfu/g | Conforms |
| Yeast &Mould | ≤100cfu/g | Conforms |
| Escherichia Coli presence | Negative | Conforms |
| Salmonella | Negative | Conforms |
| Staphylococcus | Negative | Conforms |
| Conclusion | Conform with enterprise specification | |
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Density 1.138 g/cm³
Boiling point 337.6ºC at 760 mmHg
Molecular formula C7H13NO3S
Molecular weight 191.25
Flash point 158ºC
Exact mass 191.06200
PSA 97.69000
LogP 0.82430
Mechanism of action of N-Acetyl-L-cysteine ethyl ester
Lipid-soluble penetration enhancement mechanism: The ethyl esterification modification of the carboxyl group significantly reduces polarity, resulting in significantly better lipid affinity than water-soluble NAC. It can freely penetrate hydrophobic barriers such as lipid membranes and the stratum corneum, entering the hydrophobic matrix without the need for additional penetration enhancers, thus overcoming the limitation of the parent material's inability to penetrate the lipid phase structure. Once inside, natural esterases in the system hydrolyze the ethyl ester groups, slowly releasing the free NAC active structure, achieving a long-lasting sustained-release effect.
Endogenous reducing substance replenishment mechanism: The hydrolyzed NAC structure can serve as a precursor component, helping to increase the reserve of glutathione-related reducing substances in the system, strengthening the system's own intrinsic antioxidant capacity. It not only provides single exogenous antioxidant protection but also regulates the internal reduction cycle system, effectively alleviating continuous oxidative stress.
Antioxidant Depletion Stabilization Mechanism: Its molecular structure is more stable than that of free cysteine, making it less prone to premature oxidation and inactivation. At the same time, it can protect lipid and protein active components from oxidative decomposition. In cell culture systems and emulsified skin care formulas, it reduces the loss of activity caused by light, air, and external stimuli, and prolongs the survival time of various functional components in the system.
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FAQ
01. What role does N-Acetyl-L-cysteine ethyl ester play in in vitro cell experiments?
It regulates the oxidative balance of the culture environment, reduces damage to cell structure from reactive oxygen species, and maintains normal cell culture homeostasis.
02. Can N-Acetyl-L-cysteine ethyl ester be added directly to pure water formulations?
N-Acetyl-L-cysteine ethyl ester is not recommended. Its water solubility is weak, and it disperses poorly in pure water systems. It is more suitable for oil-phase or oil-water emulsion formulations.
03. Why does N-Acetyl-L-cysteine ethyl ester need to be stored in a cool, dark, and sealed container?
Because its molecules contain reactive thiol groups, it is highly susceptible to oxidation upon contact with air and light, leading to decreased activity and material deterioration.
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Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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