what is Glycyrrhetic Acid?
Glycyrrhetic Acid is composed of two molecules of glucose aldehyde acid. White crystalline powder, taste sweet, sweetness is about 200 times that of sucrose. Its sweetness is different from sweeteners such as sucrose. After the introduction, it takes a moment to have a sweet feeling, but the retention time is long. A small amount of glycyrrhetic acid and sucrose can be used with less than 20% sucrose, but the sweetness remains unchanged. Although there is no aroma, but it has an aromatizing effect. Melting point (decomposition) 220 ℃. The aqueous solution is weakly acidic and can have an acidic effect.
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Product name |
Glycyrrhetic Acid |
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CAS |
471-53-4 |
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Molecular formula |
C30H46O4 | |
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Molecular weight |
470.69 | |
| EINECS | 207-444-6 | |
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Appearance |
white crystalline powder |
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| Melting point | 292-295 °C(lit.) | |
| Density | 0.9967 (rough estimate) |
What are the uses of Glycyrrhetic Acid?
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1 sweetening agent; sweetness modifier; flavoring agent (combined with salt, the effect is particularly great); aroma enhancer (dairy products, cocoa products, egg products, lamb, etc. for deodorization).
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what is studies of Glycyrrhetic Acid?
In vitro
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties. MTS assay demonstrates that 24 h treatment of 18β-Glycyrrhetinic acid suppresses cell proliferation in both cell lines in a dose-dependent manner. 18β-Glycyrrhetinic acid at 160 μM significantly decreases the percentage of viable cells to around 40.5±10.5% in A549 and 38.3±4.6% in NCI-H460 (p<0.01 respectively). When the cells are treated with 320 μM 18β-Glycyrrhetinic acid, a greater inhibitory effects on cell proliferation is shown, as the percentage of viable cells is below 30% compare with untreated controls (p<0.001). Treatment with 18β-Glycyrrhetinic acid at 160 μM and 320 μM decreases the levels of full-length PARP and increases the levels of cleaved-PARP
In vivo
Rats in 18β-Glycyrrhetinic acid+Triptolide (TP) group which receive low-dose 18β-Glycyrrhetinic acid (50 mg/kg) have significant reductions in the three serum parameters when compare with TP rats. Rats in 18β-Glycyrrhetinic acid+TP group which receive the high-dose 18β-Glycyrrhetinic acid (100 mg/kg) have slightly lowered the levels of three liver enzymes, the reductions do not reach statistical significance compare with TP group. Contrastingly, preadministration of low-dose 18β-Glycyrrhetinic acid protects animals from TP-induced hepatic lesions. On the contrary, low-dose 18β-Glycyrrhetinic acid (50 mg/kg) markedly suppresses the release of the four cytokines above
Product Specification
| Items | Specifications | Results | ||
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Appearance |
White crystalline powder |
Complies |
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Odor |
Odorless |
Complies |
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Taste |
Tasteless |
Complies |
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Solubility |
Easily soluble in pyridine, dissolve in ethanol or chloroform, slightly soluble in gasoline or ether, and insoluble in water |
Complies |
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Identification |
Should conform with the Standard |
Complies |
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Melting point |
288~297 ℃ |
293 ℃ |
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Clarity solution of Ethanol |
Should comply with the Standard |
Complies |
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Glycyrrhizinate |
Should comply with the Standard |
Complies |
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Loss on drying |
≤1.0% |
0.4% |
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Residue on ignition |
≤0.1% |
0.03% |
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Chloride |
≤0.1% |
0.053% |
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Heavy metals |
≤10ppm |
6ppm | ||
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Assay |
Calculated on loss on drying, the Content of 18-Beta-Glycyrrhetinic acid is no less than 97.0% |
98.6% | ||
How Glycyrrhetic Acid inhibits the proliferation of AGS cells?
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Glycyrrhetic Acid could regulate the expression of miR-328-3p, inhibit the proliferation of GC cells, arrest the cell cycle, and promote cell apoptosis. The dual-luciferase reporter gene experiment confirmed that miR-328-3p targeted the regulation of STAT3 and participated in promoting autophagy. Results suggest that 18β-GRA promoted the synthesis of autophagosomes and inhibited cell proliferation by regulating the miR-328-3p/STAT3 signaling pathway. |
How and where to buy Glycyrrhetic Acid?
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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