Lumbrokinase powder is an enzyme-active compound extracted and separated from artificially cultured Eisenia foetida. The pure product is yellowish powder, which contains Plasminogen and plasminogen activator, and some components similar to tissue plasminogen activator (t-PA). Various enzyme active substances in earthworm extract have been proved to have excellent clinical application value in facing the health problems of blood vessels.
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| Items | Specifications | Results | ||
| Character | Light yellow powder, with hygroscopicity | Complies | ||
| Odor | Characteristic | Characteristic | ||
| Identification | ||||
| 1 | Max absorption at 278nm | Complies | ||
| 2 | Positive reaction | Positive reaction | ||
| Heavy metals | ||||
| Pb | ≤1.5ppm | <1.5ppm | ||
| As | ≤1ppm | <1ppm | ||
| Hg | ≤0.1ppm | <0.1ppm | ||
| pH | 6.0-8.0 | 7.04 | ||
| Loss on drying | ≤6.0% | 4.16% | ||
| Potency | Lumbrokinase unit activity/mg ≥16000 | 16590 | ||
| Specific activity | ≥20000 unit activity/mg | 26758 | ||
| Conclusion | Complies with enterprise specification | |||
What is the principle of action of Lumbrokinase?
Lumbrokinase powder is a proteolytic enzyme. Animal experiments show that this product can dissolve rabbit arterial thrombosis and rat inferior vena cava thrombosis, and can obviously shorten the euglobulin lysis time of rabbits. Clinical experiments show that it has special affinity with thrombus (fibrin), and can track thrombolysis, adjust fibrinogen content, shorten the dissolution time of excellent protein, reduce whole blood viscosity and plasma viscosity, and increase t-PA activity. The activity of plasminogen activator inhibitor is reduced, and the degradation products of fibrin are increased, thus effectively dissolving the micro-thrombus, increasing the elasticity of blood vessels, improving the oxygen supply function of blood vessels and inhibiting the re-formation of thrombus. Repair peripheral necrotic brain cells after thrombosis and save penumbra. At present, high quality Lumbrukinase has been widely used in the prevention and treatment of cardiovascular, cerebrovascular, endocrine and respiratory diseases.
What is the clinical application and development prospect of Lumbrokinase?
Lumbrukinase raw powder can be used to prevent and treat thrombotic and embolic diseases, and it is also suitable for treating patients with increased fibrinogen and platelet aggregation rate in ischemic cerebrovascular disease, and has a remarkable effect on limb paralysis and speech disorder recovery of cerebrovascular disease. In 1560 patients with cerebral infarction, the effective rate was 93.7% and the remarkable rate was 73.6% after using lumbrokinase for 21 days, and the fibrinogen and euglobulin lysis time were significantly reduced. There are changes in hemorheology, which are statistically significant by X2 test. Except for a few patients with rash, itchy skin and nausea, there were no other adverse reactions. The clinical efficacy of lumbrokinase in the treatment of ischemic cerebrovascular disease was observed by random sampling and double-blind method. The results showed that the effective rate was 93.7% and the effective rate was 73.6%. After treatment, the fibrinogen content, euglobulin lysis time, whole blood viscosity, plasma viscosity and platelet aggregation function in the treatment group all changed significantly.
At present, clinical trials show that lumbrokinase can obviously alleviate the symptoms of cardiovascular and cerebrovascular diseases, diabetes, nephrotic syndrome, pulmonary heart disease and deep venous thrombosis of lower limbs, and the adverse reactions are small, which is easy for patients to tolerate. Although there are still many problems to be solved by large-scale and long-term clinical controlled research, looking forward to the future, the application of Lumbrukinase powder in clinical diseases will have a better prospect.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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