What is b6 pyridoxal 5 phosphate?
B6 Pyridoxal 5 Phosphate is an organic compound with molecular formula C8H10NO6P, which is formed by combining vitamin B6 with phosphoric acid, including pyridoxal, pyridoxamine and pyridoxine, and exists in the form of phosphate in the body. Among them, pyridoxal phosphate and pyridoxamine phosphate can be transformed into each other, both of which are active. b6 pyridoxal 5 phosphateis the active form of vitamin B6. Several reactions catalyzed by it include transamination, α-decarboxylation, β-decarboxylation, β-elimination, γ-elimination, racemization and aldol reaction.
It is white crystalline powder, odorless and bright yellow in alkaline solution. The aqueous solution is stable at low temperature in the dark, and gradually decomposes when it sees light.
| Product name | b6 pyridoxal 5 phosphate |
| CAS | 54-47-7 |
| Molecular formula | C8H10NO6P |
| Molecular weight | 247.14 |
| EINECS | 200-208-3 |
| melting point | 74-76oC |
| boiling point | 565.7±60.0 °C(Predicted) |
| density | 1.638±0.06 g/cm3(Predicted) |
| Storage condition | Inert atmosphere,Store in freezer, under -20°C |
What is the synthesis method of b6 pyridoxal 5 phosphate?
The synthesis methods of this product can be divided into two categories: chemical method and enzymatic method, among which enzymatic method has attracted much attention because of its simple operation, environmental protection and suitability for industrial production.
Core steps
Enzyme carrier: immobilized enzyme (such as Escherichia coli containing phosphotransferase and alcohol oxidase genes) is used to separate enzyme protein through crushing and centrifugation;
Reaction flow: substrate pyridoxine is catalyzed by phosphotransferase in an enzyme reactor to generate pyridoxal phosphate, and then oxidized by alcohol oxidase to obtain b6 pyridoxal 5 phosphate product.
What are the physiological functions and uses of b6 pyridoxal 5 phosphate?
B6 Pyridoxal 5 Phosphate is a coenzyme form of vitamin B6. In the catalytic reaction, the aldehyde group in pyridoxal phosphate molecule combines with the amino group of α -amino acid to form aldimine, also known as Schiff base, and then the amino acid is transamination, decarboxylation or racemization according to the characteristics of different enzyme proteins. As a coenzyme of amino acid transaminase, decarboxylase and racemase, b6 pyridoxal 5 phosphate plays an important role in amino acid metabolism.
b6 pyridoxal 5 phosphate is an important substance in pyridoxal, which is not only the coenzyme of transaminase and decarboxylase in amino acid metabolism, but also can promote the decarboxylation of glutamic acid and the production of γ -aminobutyric acid. Pyridoxaldehyde phosphate is also widely used in the synthesis of β -carbonyl amide drugs, biological activity research and other fields, for example, it is mainly used to treat Parkinson's disease in clinic, promote transaminase transamination and improve dopamine content in the body.
b6 pyridoxal 5 phosphate is one of the components of vitamin B6, which can promote gluconeogenesis, participate in the formation of heme, neurotransmitters and other substances, regulate immune function and steroid hormones, and participate in the conversion reaction of homocysteine. If it is necessary to use this product, it is suggested that the doctor should follow the doctor's advice after diagnosing and evaluating the condition, so as to avoid adverse reactions.
Product Specification
| Item | Specifications | Result | ||||
|
Appearance |
White to off-white Powder |
Complies |
||||
| Assay (by HPLC) | 97.0% ~ 103.0% | 99.78% | ||||
| Heavy Metals(as Pb) | ≤0.0010% | <0.0010% | ||||
| Total impurities | ≤1.0% | Not detected | ||||
| Individual impurities | ≤0.3% | Not detected | ||||
| Lead | ≤0.5mg/kg | <0.5 mg/kg | ||||
| Arsenic | ≤3mg/kg | <3 mg/kg | ||||
| Mercury | ≤0.1mg/kg | <0.1 mg/kg | ||||
| Cd | ≤0.005mg/kg | <0.005mg/kg | ||||
| Total plate count | ≤1000cfu/g | 30 cfu/g | ||||
| Mould and yeast | ≤100cfu/g | 0 cfu/g | ||||
| E.coli | Negative | Negative | ||||
| Salmonella | Negative | Negative | ||||
| Conclusion: The test results are conformed to the in-house specification | ||||||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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