Fmoc-Leu-OH Introduction
Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.
As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.
Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.
Fmoc-Leu-OH is a white solid, CAS number 35661-60-0; molecular formula C21H23NO4; molecular weight: 353.41; EINECS number: 252-662-7. FMOC-L-Leucine is a commonly used modified amino acid monomer on the market, mainly obtained through chemical synthesis. It is widely used in the preparation of pharmaceutical peptides, cosmetic active peptides, and various biochemical research.
What is the use of Fmoc-Leu-OH?
The main applications of the FMOC-L-Leucine core component can be summarized into two aspects. Firstly, it is widely used in compound research and biochemical experiments, and is a commonly used building block in peptide synthesis. The molecule's inherent Fmoc protective group can shield the amino terminus of leucine, allowing for the targeted attachment of the leucine fragment during solid-phase peptide chain synthesis. This facilitates the preparation of peptide raw materials with antibacterial and anti-tumor effects in the laboratory, as well as the synthesis of active peptide raw materials for cosmetics.
Secondly, this substance has its own unique biological activity. Scientific research tests have confirmed that it can selectively regulate the PPARγ pathway. Compared with conventional hypoglycemic compounds, it enhances insulin sensitivity in the body, stabilizes blood sugar levels, and does not cause typical adverse reactions such as weight gain. It is a potential lead compound for type 2 diabetes. Additionally, animal model experiments have also verified its anti-inflammatory effect, which can improve various inflammatory-related conditions such as dermatitis and intestinal inflammation.
What is the future prospect of Fmoc-Leu-OH?
The potential of Fmoc-Leu-OH lies in two related fields. From the perspective of the peptide raw material market, this product is a commonly used core material in solid-phase peptide synthesis, and the industry trend is entirely dependent on the overall development of peptide products. Currently, several new peptide products such as GLP-1 hypoglycemic peptides have been launched and achieved commercialization expansion. The industry's demand for high-purity Fmoc-protected amino acid building blocks will also steadily increase. Long-term order demand has a stable support.
However, its own pharmacological research and development value has more room for exploration. Relevant test data show that FMOC-L-Leucine is a selective PPARγ regulator. In normal mice and diabetic animal models, it can significantly improve insulin sensitivity and has a hypoglycemic effect comparable to Rosiglitazone. However, its effect on promoting fat accumulation is weak, which can avoid the shortcoming of traditional hypoglycemic products that are prone to causing weight gain.
In addition, its anti-inflammatory performance is also remarkable. In animal experiments, it can inhibit the aggregation of neutrophils and improve the discomfort symptoms of various inflammatory models such as dermatitis, arthritis, and intestinal inflammation. It can also form a hydrogel in specific environments. This physicochemical characteristic also expands its application scenarios in product delivery carriers and tissue engineering biomaterials.
MF of Fmoc-Leu-OH
| CAS | 35661-60-0 |
| Molecular formula | C21H23NO4 |
| Molecular weight | 353.41 |
| EINECS | 252-662-7 |
| Melting point | 152-156 °C |
| Density | 1.2107 |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Identification | Positive reaction | Positive reaction |
| Related substances | ≤1.0% | 0.16% |
| Loss on drying | ≤0.5% | 0.06% |
| Residue on ignition | ≤0.1% | 0.02% |
| Heavy Metals | ≤20ppm | <20ppm |
| Clarity of solution | Conform to standard | Complies |
| Microbial Limit | ≤20ppm | <20ppm |
| Assay | ≥99.0% | 99.12% |
| Conclusion | Conform with enterprise specification | |
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A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide FMOC-L-Leucine etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:What do "Fmoc" and "Leu" stand for in Fmoc-Leu-OH?
"Leu" stands for DL-Leucine, one of the 20 essential amino acids that make up human proteins. "Fmoc" is a chemical protecting group that protects leucine during synthesis, preventing it from forming random bonds.
Q2:Is Fmoc-Leu-OH safe? Is it dangerous?
It is safe under normal laboratory conditions and is not classified as a hazardous material. However, it is slightly irritating to the skin, eyes, and respiratory tract, and should not be ingested or come into contact with everyday items.
Q3:What is the difference between Fmoc-Leu-OH and regular leucine?
The latter can be obtained from food and is a naturally occurring amino acid in the human body.
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