what is Hydroxocobalamin powder?
Hydroxocobalamin powder is an intermediate for the synthesis of nitrocobalamin and a useful intermediate for the synthesis of cobalamin acetate; Physiological analogues of vitamin B12, in which the CN group is replaced by OH. It exists in aqueous solution as an equilibrium mixture of hydroxyl isomer and aquacobalamin. Coenzyme methylcobalamin and its precursors. Coordination compounds.
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Product name |
Hydroxocobalamin |
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CAS |
13422-51-0 |
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Molecular formula |
C62H90ClCoN13O15P | |
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Molecular weight |
1382.82 | |
| EINECS | 236-533-2 | |
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Appearance |
dark red crystalline powder |
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| Melting point | >300℃ | |
| Storage |
2-8°C |
What are the uses of Hydroxocobalamin powder?
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Vitamin B12 Deficiency: Hydroxocobalamin powder is used to prevent and treat low vitamin B12 levels, particularly in individuals with pernicious anemia or malabsorption issues. Cyanide Poisoning: It can be used as an antidote to cyanide poisoning by binding to the cyanide and forming a non-toxic compound that is excreted. Leber's Optic Atrophy: It may be part of the treatment for this inherited optic neuropathy, which is associated with vitamin B12 deficiency. Toxic Amblyopia: It may be used in the treatment of vision loss caused by toxic substances. |
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What are the Pharmacodynamics of Hydroxocobalamin powder?
Hydroxocobalamin is a synthetic, injectable form of Vitamin B12. Hydroxocobalamin powder is actually a precursor of two cofactors or vitamins (Vitamin B12 and Methylcobalamin) which are involved in various biological systems in man. Vitamin B12 is required for the conversion of methylmalonate to succinate. Deficiency of this enzyme could therefore interfere with the production of lipoprotein in myelin sheath tissue and so give rise to neurological lesions. The second cofactor, Methylcobalamin, is necessary for the conversion of homocysteine to methionine which is essential for the metabolism of folic acid. Deficiency of tetrahydrafolate leads to reduced synthesis of thymidylate resulting in reduced synthesis of DNA which is essential for cell maturation. Vitamin B12 is also concerned in the maintenance of sulphydryl groups in reduced form, deficiency leading to decreased amounts of reduced SH content of erythrocytes and liver cells. Overall, vitamin B12 acts as a coenzyme for various metabolic functions, including fat and carbohydrate metabolism and protein synthesis. It is necessary for growth, cell replication, hematopoiesis, and nucleoprotein as well as myelin synthesis. This is largely due to its effects on metabolism of methionine folic acid, and malonic acid.
Product Specification
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Items |
Specifications |
Results |
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Appearance |
dark red crystalline powder |
Conforms |
| Identification | complies | Conforms |
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Assay |
≥96% |
99.1% |
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Loss on Drying |
≤12% |
5% |
| Related substance | ≤4.0% | 2.3% |
|
peseudoCyanocobalamin |
complies | Conforms |
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E Coli enrichment |
Negative/ 10g |
Absent |
|
Salmonella |
Negative/ 10g |
Absent |
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Total Aerobic Plate |
NMT 1000 cfu/g |
Conforms |
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Count Yeast and Mold |
NMT 100 cfu/g |
Conforms |
Conclusion：Conform with specification and qualified.
What is the mechanism of action of Hydroxocobalamin powder?
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the mechanism of Hydroxocobalamin powder involves its conversion to active coenzymes that participate in critical metabolic pathways, its high affinity for plasma proteins which prolongs its efficacy, and its ability to neutralize toxic substances like cyanide and excess nitric oxide. These properties make hydroxocobalamin a versatile and essential compound in both nutritional supplementation and medical treatments.
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How and where to buy Hydroxocobalamin powder?
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A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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