what is amygdalin b17?
A β - cyanogenic glycoside in bitter almonds, with a cyanide group (CN) bound to its molecule. After bitter almonds are harvested, free cyanide groups are released, which can cause poisoning to the eater; Amygdalin B17 is a product of phenylalanine metabolism in bitter almonds. There are β - glucosidase and oxynitrilase in bitter almonds. The former catalyzes the hydrolysis of amygdalin into two molecules of glucose and one molecule of amygdalone, while the latter catalyzes the hydrolysis of amygdalone into cyanide (HCN) and benzaldehyde. Bitter almond glycoside exists in seeds, such as almonds.
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Product name |
amygdalin b17 |
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CAS |
29883-15-6 |
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Molecular formula |
C20H27NO11 | |
|
Molecular weight |
457.43 | |
| EINECS | 249-925-3 | |
|
Appearance |
white powder |
|
| Melting point | 223-226 °C | |
| Density |
563.27°C (rough estimate) |
What is the source of amygdalin b17?
Amygdalin b17 is a toxic cyanide glycoside found in many plants, but most notably in the seeds of plants such as apricots, bitter almonds, apples, peaches, and plums. Bitter almond glycoside is also present in other plum plants, including apricots and black cherries, as well as in the leaves, fruits, and nuclei of loquat.
What are the functions and uses of amygdalin b17?
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Amygdalin B17, After enzymatic decomposition, hydrogen cyanide is formed. Hydrogen cyanide is toxic but has a sedative effect on the respiratory center in small amounts. Therefore, literature records that it has cough suppressant and asthma relieving effects, as well as killing typhoid bacilli and other bacteria. In recent years, domestic and foreign scientific research has shown that hydrogen cyanide also has anti-cancer effects. Amygdalin B17 is a cyanide containing glycoside that can be used as a substrate to identify, differentiate, and characterize enzymes such as maltase, lactase, and β - glucosidase. |
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Product Specification
|
Items |
Specifications |
Results |
| Assay | ≧98.5% | 99.3% |
|
Appearance |
white crystalline powder |
Conforms |
|
Odor |
Characteristic |
Conforms |
|
Taste |
Characteristic |
Conforms |
|
Extract Solvent |
Ethanol & water |
Conforms |
|
Excipient |
None |
Conforms |
|
Particle Size |
NLT100%Through 80 mesh |
Conforms |
|
Loss on Drying |
≦1.5% |
0.73% |
|
Ash content |
≦0.20% |
0.06% |
|
Residual Solvent |
<3000ppm |
ETHANOL:780pp |
|
Melting Point |
215.3℃～217.6℃ |
215.3℃～217.6℃ |
|
optical rotation [α]20 |
-40° ~ -45° |
-42° |
|
Total Heavy Metals |
≤5.0ppm |
Conforms |
|
As |
≤0.1ppm |
Conforms |
|
Pb |
≤0.1ppm |
Conforms |
|
Hg |
≤0.01ppm |
Conforms |
|
Cd |
≤0.01ppm |
Conforms |
|
Total Impurities |
≦1.0% |
0.52% |
|
Any other single impurity |
≦0.5% |
0.19% |
|
Total Plate Count |
≤1000cfu/g |
Conforms |
|
Total Yeast & Mold |
≤100cfu/g |
Conforms |
|
E.Coli |
Negative |
Negative |
|
Salmonella |
Negative |
Negative |
Conclusion：Conform with specification and qualified.
How to Separate Amygdalin B17?
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For one method of isolating amygdalin b17, the stones are removed from the fruit and cracked to obtain the kernels, which are dried in the sun or in ovens. The kernels are boiled in ethanol; on evaporation of the solution and the addition of diethyl ether, amygdalin is precipitated as minute white crystals. Natural amygdalin has the (R)-configuration at the chiral phenyl center. Under mild basic conditions, this stereogenic center isomerizes; the (S)-epimer is called neoamygdalin. Although the synthesized version of amygdalin is the (R)-epimer, the stereogenic center attached to the nitrile and phenyl groups easily epimerizes if the manufacturer does not store the compound correctly.
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Is Amygdalin B17 safe?
Amygdalin B17 is hydrolyzed by intestinal β-glucosidase (emulsin)and amygdalin beta-glucosidase (amygdalase) to give gentiobiose and L-mandelonitrile. Gentiobiose is further hydrolyzed to give glucose, whereas mandelonitrile (the cyanohydrin of benzaldehyde) decomposes to give benzaldehyde and hydrogen cyanide. Hydrogen cyanide in sufficient quantities (allowable daily intake: ~0.6 mg) causes cyanide poisoning which has a fatal oral dose range of 0.6–1.5 mg/kg of body weight.
How and where to buy amygdalin b17?
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Shipping method |
Cargo weight requirements |
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