Thymine Powder CAS 65-71-4

Thymine powder was first discovered and isolated from calf thymus, also known as 5-METHYLURACIL. White dendrite, needle crystal or crystalline powder. Pure thymine is easy to sublimate, soluble in hot water and lye, and has strong absorption of ultraviolet rays. At present, the main raw material of thymine for scientific research is prepared from deoxyribonucleic acid hydrolysis, which has high purity and stable yield.

How was thymine obtained?

Thymosin was initially discovered by hydrolyzing natural calf thymus and was found to be the main pyrimidine component in deoxyribonucleic acid. It is also an important precursor of thymine in the biosynthesis process of deoxyribonucleic acid, and is linked to deoxyribose through glycosidic chains to form deoxythymidine. Its triphosphate compound is deoxythymidine triphosphate; People's interest in its direct chemical synthesis began with the increasing demand in the medical industry in the 20th century. However, at that time, the hydrolysis of deoxyribonucleic acid to produce this product could only meet the needs of laboratories and could not meet the great development of the medical industry. At the end of the 20th century, scientists used a condensation reaction between methyl isothiocyanate and ethyl formylpropionate, followed by hydrolysis of pyrimidine intermediates, making it more practical to obtain thymine powder

What are the uses of Thymine?

5-METHYLURACIL powder is a pyrimidine base and one of the four nucleotides (G-C-A-T) that form DNA nucleotides. 5-methylpyrimidine is an important component of genetic material, a key intermediate for the synthesis of anti AIDS drugs AZT, DDT and related drugs, and also the starting material for the synthesis of anti-tumor and antiviral drugs β-Thymidine 50-89-5. In addition, thymidine can be used in genetic research to study chemical processes that affect DNA structure, such as radiation-induced free radical products leading to base cross-linking reactions and derivatization reactions

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