Lappaconitine Hydrobromide CAS 97792-45-5
Product Name:Lappaconitine Hydrobromide powder;Lappaconitine Hydrobromide
CAS NO.:97792-45-5
Molecular Formula:C32H45BrN2O8
Purity & Grade: 99% HPLC; Medicine grade
MOQ & Package: 10g; Package according to demand
Shipping: Safe and fast delivery
Store & Shelf life: Cool & dry place; 24 months
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
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Description
Product Introduction
Lappaconitine hydrobromide is a diterpene alkaloid isolated from Aconitum raphani of the Ranunculaceae family. Its chemical name is (1α,14α,16β)-20-ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-[2-(acetylamino)benzoate hydrobromide monohydrate. It is the first non-addictive analgesic drug in China. It has analgesic, antipyretic, detumescent and local anesthetic effects, and has no accumulation effect.
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| Lappaconitine Hydrobromide Picture | Lappaconitine Hydrobromide MF |
Product Application
Lappaconitine hydrobromide has the following effects:
1. Analgesic effect: It can significantly relieve the thermal pain sensation of rats with chronic constrictive injury (CCL), achieve analgesic therapeutic effect, and has no obvious toxic reaction.
2. Anti-inflammatory effect: Lappaconitine has a significant inhibitory effect on xylene-induced swelling of mouse ear shells, rat arthritis foot swelling, and rat agar granuloma hyperplasia. This shows that Lappaconitine has anti-acute and chronic inflammatory effects, which provides a theoretical basis for the clinical treatment of pain and swelling caused by rheumatic and rheumatoid arthritis.
3. Anti-tumor effect: The tumor inhibition rate of Lappaconitine on mouse liver cancer is 11.20%-53.08%, and the tumor inhibition rate on mouse S180 is 29.81%-53.%.
4. Anti-arrhythmic effect: Lappaconitine can increase the normal threshold of arrhythmia induced by aconitine in rats, and can significantly improve myocardial ischemic arrhythmia in dogs, thereby reducing the incidence of arrhythmia.
The plasma elimination half-life (tl/2), clearance rate CL and apparent distribution volume V of LAPPACONITINE HYDROBROMIDE have no significant difference at high, medium and low doses, that is, the pharmacokinetic parameters of the drug basically do not change with the change of dose, showing linear kinetic behavior. The drug-time process in the body conforms to the two-compartment open model, with rapid absorption and moderate elimination rate.
Extraction method of LAPPACONITINE HYDROBROMIDE: Crush the root tubers of Aconitum raphanus → add to the extraction tank, add ethanol to soak for 1 hour, heat and reflux for 3 hours 3 times → concentrate, acidify with 2% hydrochloric acid, filter → add ammonia water to alkalize to pH 9-10, stir and precipitate, filter → dissolve the precipitate with chloroform → add process water, let stand and separate → add anhydrous potassium carbonate, stir and dehydrate, reduce pressure and filter until it becomes a paste → dissolve with ethanol, recover ethanol until crystals are precipitated → obtain Lappaconitine hydroxylamine.
Product Specification
| Item | Specification | Result |
| Assay | 98% | 99.62% |
| Appearance | White to off white powder | conforms |
| Odor | Characteristic | conforms |
| Taste | Characteristic | conforms |
| Particle Size | NLT 100% Through 80 mesh | conforms |
| Loss on Drying | <2.0% | 0.46% |
| Heavy metals | ||
| Total Heavy Metals | ≤10ppm | conforms |
| Arsenic | ≤3ppm | conforms |
| Lead | ≤3ppm | conforms |
| Microbiological Tests | ||
| Total Plate Count | ≤1000cfu/g | conforms |
| Total Yeast & Mold | ≤100cfu/g | conforms |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion | Conform with the enterprise standard | |
How To Obtain Samples Lappaconitine hydrobromide?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API Lappaconitine hydrobromide.
The Best Lappaconitine hydrobromide Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Lappaconitine hydrobromide?
Faithfulbio specialize in Lappaconitine hydrobromide for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use Lappaconitine hydrobromide for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Lappaconitine hydrobromide?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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