Levocetirizine dihydrochloride is the R-isomer of Cetirizine dihydrochloride and a new generation of highly effective non sedating antihistamines. Its affinity for H1 receptors is twice that of cetirizine hydrochloride, and the effective dose is half that of cetirizine hydrochloride. Clinical results have shown that it has advantages over loratadine, ebastine, Mizolastine, and Fexofenadine. Pure Levocetirizine dihydrochloride USP is a white hygroscopic powder used to treat seasonal allergic rhinitis, perennial allergic rhinitis, allergic conjunctivitis, chronic idiopathic urticaria, etc.
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ITEMS |
SPECIFICATION |
RESULTS |
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CHARACTE RS
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DESCRIPTION |
WHITE TO OFF-WHITE POWDER |
OFF-WHTIE POWDER |
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SOLUBILITY |
FREELY SOLUBLE IN WATER,SLIGHTLY SOLUBLE IN ISOPROPANOL AND IN ACETONITRILE |
CONFORM |
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IDENTIFICATION |
1)INFRARED ABSORPTION SPECTROPHOTOMETRY CORRESPONDS TO REFERENCE STANDARD |
CONFORMS |
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2)ULTRAVIOLE ABSORPTION SPECTROPHOTOMETRY CORRESPONDS TO THE REFERENCE STANDARD |
CONFORMS |
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3)TEST FOR POTASSIUM SHOULD BE POSITIVE |
C0NFORMS |
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WATER(KF) |
≤ 0.5% |
0.3% |
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HEAVY METALS |
≤10PPM |
<10PPM |
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RELATED SUBSTANCES(HPLC) |
Individual impurity≤ 0.2% |
0.07% |
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Total impurity≤ 0.5% |
0.12% |
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RESIDUAL SOLVENTS(GC) |
CYCLOHEXANE ≤1000PPM |
< LOQ(LOQ:50PPM) |
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ISOPROPANOL ≤ 2000PPM |
178PPM |
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ASSAY(HPLC) |
98.5%-101.0% CALCULATED ON ANHYDROUs,SOLVENT-FREE BASIS |
100% |
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CONCLUSION |
COMPLIES WITH USP36 |
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What is the difference between cetirizine hydrochloride and Levocetirizine dihydrochloride?
There are differences in molecular structure and efficacy between Levocetirizine dihydrochloride and cetirizine hydrochloride.
1, Different molecular structures: Cetirizine dihydrochloride is a racemic form containing both Left-handed structure and right-handed structure; The product ingredients of Levocetirizine dihydrochloride only contain left-handed structures.Experimental results have shown that the left-handed structure is the effective active ingredient of cetirizine, with a high selectivity for H1 receptors that is 30 times that of cetirizine. At the same time, this product does not have significant anticholinergic or anti serotonin effects, and its central inhibitory effect is relatively small. However, it can effectively inhibit the accumulation of eosinophils. Reasonable use of this product is a pathway to obtain highly efficient, selective, and competitive peripheral H1 receptor antagonists.
2, Different pharmacological effects: According to relevant experimental data, the binding capacity of levocetirizine hydrochloride to human H1 histamine receptor is 30 times that of cetirizine hydrochloride. Therefore, at the same dose, Levocetirizine dihydrochloride USP has a stronger antihistamine effect than Cetirizine dihydrochloride, and the causes of adverse reactions are significantly reduced. In addition, the classification and management of these two drugs are also different. However, regardless of the differences between them, it is necessary to consult your physician first during the research or usage phase.
Our company can provide Levocetirizine dihydrochloride, cetirizine hydrochloride, loratadine, ebastine, Mizolastine,Fexofenadine and so on. at low prices. If you are interested, please leave a message by email:sales6@faithfulbio.com
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| 130018-87-0 Levocetirizine dihydrochloride | 83881-52-1 Cetirizine dihydrochloride | 90729-43-4 Ebastine | 83799-24-0 Fexofenadine |
What are the efficacy and effects of levocetirizine hydrochloride tablets?
The main ingredient of levocetirizine hydrochloride tablets is levocetirizine hydrochloride, which is mainly used to treat allergic diseases. Its main functions and effects are anti allergic, anti itch, relieving urticaria, treating eczema, improving asthma, etc. It is recommended to use specific medications under the guidance of a doctor.
1. Antiallergy : Levocetirizine hydrochloride tablets are an antihistamine that can inhibit histamine release, which is one of the main mediators causing allergic reactions.
2. Antipruritic : By stabilizing the mast cell membrane and reducing the release of its sensitizing factors, the goal of relieving itching can be achieved.
3. Relieve urticaria: It can alleviate the symptoms of urticaria and quickly control the condition for acute attacks of urticaria.
4. Treating eczema: selectively antagonizing peripheral tissue H1 receptors, inhibiting mast cell degranulation, and preventing the release of inflammatory mediators have a certain therapeutic effect on chronic eczema.
5. Improving asthma: It can effectively inhibit the release of inflammatory mediators by mast cells, reduce bronchial constriction and mucus secretion, thereby improving the respiratory function of asthma patients.
In addition, it can also alleviate the symptoms of allergic rhinitis and allergic conjunctivitis. During the use of pure Levocetirizine dihydrochloride, it is necessary to avoid driving motor vehicles or operating machinery to prevent accidents caused by adverse reactions such as drowsiness. Individuals with a history of liver dysfunction or disorders should use caution, and symptomatic and supportive treatment is recommended after overdose. After taking this medication, adverse reactions such as headache, drowsiness, dry mouth, and fatigue may occur. If the symptoms are severe or persistent, it is recommended to seek medical attention promptly.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can offer Levocetirizine dihydrochloride, cetirizine hydrochloride, loratadine, ebastine, Mizolastine,Fexofenadine and so on. at a low price. If you need it, please leave a message
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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