Rafoxanide API Powder CAS 22662-39-1
Product Name:Rafoxanide
Synonym:3’-chloro-4’-(p-chlorophenoxy)-3,5-diiodo-salicylanilid;bovanide;duofas;flukanide;Rafoxanide 0.1;Disalan
CAS NO.:22662-39-1
EINECS NO.:245-148-9
Molecular Formula:C19H11Cl2I2NO3
Purity & Grade: 99%; Medicine grade
Character:White powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 5-10 days
Store & Shelf life: Cool & dry place; 24 months
Description
What is Propanamide?
For over a decade, Xi'an Faithful BioTech Co., Ltd. has been deeply involved in the fields of fine chemicals, active plant and animal ingredients, and livestock-related raw materials, boasting a rich and diverse product line. Our company consistently adheres to the development philosophy of prioritizing quality and operating with integrity. With consistently outstanding product quality and professional and comprehensive support services, our products are sold to numerous countries and regions worldwide, establishing a strong brand reputation in both domestic and international markets. We are a trustworthy and high-quality partner in the industry. Rafoxanide API Powder belongs to the halosalicylaniline class of compounds with the molecular formula C₁₉H₁₁Cl₂I₂NO₃ and a molecular weight of 626.01. It appears as a grayish-white to light brown crystalline powder, exhibiting stable physicochemical properties and being almost insoluble in water. Discovered in 1969, this substance has become a highly valuable functional ingredient in the livestock industry due to its unique mechanism of action. It acts on mitochondria, disrupting oxidative phosphorylation through uncoupling effects, thus inhibiting normal energy production and achieving an inhibitory effect on harmful organisms. It exhibits excellent effects against common ruminant worms such as liver flukes, gastrointestinal nematodes, and nasal fly larvae, showing good efficacy against worms at different growth stages, with broad application coverage and stable performance. With the continuous development of biotechnology, the potential value of this substance is being continuously explored. Related studies have confirmed that it can regulate multiple key signaling pathways, induce endoplasmic reticulum stress and cell cycle arrest, and shows considerable potential in tumor-related research. Rafoxanide API Powder can also act on bacterial structure, inhibit bacterial efflux mechanisms, effectively improve the problem of multidrug-resistant strains, and provide a new research direction for problems related to stubborn bacterial communities.
Rafoxanide Manufacturing Process
Using 3,5-Diiodosalicylic acid as the main raw material, after acylation treatment, it undergoes a condensation reaction with 3-CHLORO-4-(4-CHLOROPHENOXY)ANILINE. After the reaction is completed, the mixture is cooled for crystallization, filtered for separation, washed with a special solvent, and finally dried and purified to obtain a high-purity iodosalicylic acid product. The reaction conditions and quality testing are strictly controlled throughout the entire process.
COA
| Test Item | Specification | Result |
| Appearance | White to light yellow to light orange powder | Complies |
| Identification(HPLC) | Retention time of sample matches reference standard |
Complies |
| Assay | ≥99.0% | 99.6% |
| Related Substances | Any Individual Impurity≤0.1% | 0.03% |
| Total Impurities≤1.0% | 0.35% | |
| Loss on Drying | ≤0.5% | 0.18% |
| Residue on lgnition | ≤0.1% | 0.04% |
| Heavy Metals | Lead (Pb)≤2.0 ppm | Complies |
| Cadmium(Cd)≤1.0 ppm | Complies | |
| Mercury(Hg)≤0.1 ppm | Complies | |
| Total Heavy Metals≤10 ppm | Complies | |
| Microbial Limits | Total Plate Count<1000cfu/g | <100cfu/g |
| Yeast &Moulds<100cfu/g | <10cfuv/g | |
| E.Coli Negative | Negative | |
| Salmonella Negative | Negative | |
| Conclusion | Conform with enterprise specification | |
Click email：sales4@faithfulbio.com Or WhatsApp：+86 17782784907
Density: 2.0±0.1 g/cm³
Boiling point: 526.6±50.0 °C at 760 mmHg
Melting point: 169ºC
Molecular formula: C19H11Cl2I2NO3
Molecular weight: 626.010
Flash point: 272.3±30.1 °C
Exact mass: 624.820496
PSA: 58.56000
LogP: 9.36
Mechanism of action of Rafoxanide
Interference with energy metabolism: As a mitochondrial uncoupling agent, it disrupts oxidative phosphorylation, blocks energy synthesis, and causes the parasite to lose its activity.
Tumor-suppressing pathways: It inhibits pathways such as BRAF, STAT3, and NF-κB, inducing cell cycle arrest and apoptosis.
why choose us
We adhere to the principle of "customer first, honesty first", and always provide customers with high-quality and efficient products and high-quality services. Choose faithfulness. Choose a healthy life!
With our continuous efforts and good service, we sincerely hope to establish long-term cooperation and common development with customers and give us a chance. We believe that we will satisfy you with first-class quality, safe and fast delivery and enthusiastic after-sales service.
Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
01. What is the core mechanism of action of Rafoxanide against parasites?
As a mitochondrial uncoupling agent, it disrupts oxidative phosphorylation, blocks energy production, and thus inhibits parasite activity.
02. Which harmful parasites is Rafoxanide primarily effective against?
It has good effects on liver flukes, gastrointestinal nematodes, and nasal fly larvae in ruminants, and can act on parasites at all growth stages.
03. What are the roles of Rafoxanide in tumor research?
Rafoxanide API Powder can inhibit multiple carcinogenic signaling pathways, induce endoplasmic reticulum stress and cell cycle arrest, and promote apoptosis in diseased cells.
Click email：Sales4@Faithfulbio.Com Or WhatsApp：+86 17782784907
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