Cefotaxime API Powder CAS 63527-52-6

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Cefotaxime Introduction

Cefotaxime API powder is a white to off-white solid powder with some hygroscopic properties. It belongs to the third-generation cephalosporin PIERICIDIN A and has broad-spectrum activity against both Gram-negative and Gram-positive bacteria.

CAS: 63527-52-6; Molecular formula: C16H17N5O7S2; Molecular weight: 455.47; EINECS: 264-299-1; Its melting point is >158℃.Cefotaxime is a third-generation semi-synthetic cephalosporin PIERICIDIN A. It is first obtained from microbial fermentation as the core raw material 7-ACA, and then processed chemically to become the final product. This product has a broad antibacterial spectrum and is commonly used in clinical settings to treat bacterial infections in the respiratory, urinary, abdominal, and central nervous system regions. It can also be used for the prevention and treatment of livestock diseases and related scientific research experiments.

What is the mechanism of action of Cefotaxime?

Cefotaxime API powder belongs to the β-lactam class, PIERICIDIN A. It binds to Penicillin G-binding proteins on the bacterial cell membrane, inhibiting the function of transpeptidase and hindering the formation of peptidoglycan in the bacterial cell wall. With the cell wall damaged, the bacteria swell and rupture due to internal osmotic pressure imbalance, ultimately leading to their death. Furthermore, its methoxyimine structure effectively resists the damage caused by β-lactams (EC 3.5.1.4), thus exhibiting good antibacterial effects against most Gram-negative bacilli.

What are the advantages of Cefotaxime?

Cefotaxime is widely used clinically, primarily for moderate to severe infections caused by susceptible bacteria.

Cefotaxime API powder can address infections in multiple body systems, including lower respiratory tract infections such as the lungs and trachea, various urinary and reproductive system inflammations, and even central nervous system disorders like meningitis. It is also a common choice for related infections in children. In addition, it is effective against severe systemic infections, abdominal, bone and joint, gynecological, and skin and soft tissue infections.

This substance can penetrate the blood-brain barrier, forming an effective concentration at the lesion site. It also shows good inhibitory effects on many resistant strains that produce β-internal EC 3.5.1.4. Clinically, it is also used for preoperative protection in surgery to reduce the possibility of subsequent infections.

MF of Cefotaxime

CAS	63527-52-6
Molecular formula	C16H17N5O7S2
Molecular weight	455.47
EINECS	264-299-1
Melting point	>158°C
Density	1.80±0.1 g/cm3

Specification

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FAQ: 

Q1:Which type of PIERICIDIN A does Cefotaxime belong to?
Cefotaxime is a third-generation cephalosporin antibiotic.
Q2: What are common Cefotaxime side effects?
The most common side effects are gastrointestinal discomfort, such as diarrhea, nausea, and vomiting. Some people may experience skin allergic reactions such as rashes and itching. In rare cases, it may affect blood test results or cause transient liver function abnormalities.
Q3:What is the difference between Cefotaxime and Ceftriaxone?

Cefotaxime API powder can deal with Pseudomonas aeruginosa, but Ceftriaxone cannot. Furthermore, the half-life of the former is longer than that of the latter.

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