Product description
Obeticholic Acid Powder, also known as 6-ethyl goosenodeoxycholic acid, is a novel derivative of Chenodeoxycholic acid (CDCA) in human primary bile acids and a natural ligand for farnesate derivative X receptor (FXR). Obecholic acid is a farnesol X receptor agonist, which indirectly inhibits cytochrome 7A1 (CYP7A1) gene expression by activating farnesol X receptor. Because CYP7A1 is a rate-limiting enzyme for cholic acid biosynthesis, obecholic acid can inhibit cholic acid synthesis and is used in the treatment of primary biliary cirrhosis and non-alcoholic fatty liver disease.
PBC is a chronic cholestasis caused by bile duct dysplasia or bile acid metabolism disorder, which causes lipid dissolution of cell membrane, permeability change, cell content flow out, and eventually progress to liver fibrosis and cirrhosis. At present, ursodeoxycholic acid is the main drug used in clinical treatment of PBC. Ursodeoxycholic acid stimulates hepatobiliary secretion through intracellular signaling molecule mitogen-activated protein kinase (MAPK) pathway, and protects epithelial cells from bile acid destruction.
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COA
| ltems | Standard | Results |
| APPEARANCE | Off white to white powder | White powder |
| IDENTIFICATION | A: IR B: Retention time |
Complies Complies |
| WATER | ≤0.5% | 0.06% |
| HEAVY METALS | ≤0.002% | Complies |
| ISOMERS | SFBD1≤0.15% | Undetected |
| SFBD2≤0.15% | Undetected | |
| SFBE≤0.15% | Undetected | |
| RESIDUE SOLBENTS | Methanol≤3000ppm | Undetected |
| Isopropyl alcohol≤5000ppm | 19ppm | |
| Dichloromethane≤600ppm | Undetected | |
| Tetrahydrofuran≤720ppm | Undetected | |
| Acetic acid≤5000ppm | Undetected | |
| Toluene≤890ppm | Undetected | |
| ASSAY | ≥99% | 99.80% |
| Conclusion: | Conform with enterprise specification. | |
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How safe is obeticholic acid?
OCA is contraindicated for patients with complete biliary obstruction. Obeticholic acid is also contraindicated for patients with decompensated cirrhosis (eg, Child-Pugh class B or C) or compensated cirrhosis with evidence of portal hypertension, such as gastroesophageal varices, ascites, or ongoing thrombocytopenia.
What is another name for obeticholic acid?
Obeticholic Acid Powder (OCA), is a semi-synthetic bile acid analogue which has the chemical structure 6α-ethyl-chenodeoxycholic acid. It is used as a medication used to treat primary biliary cholangitis.
What is the generic for obeticholic acid?
It can be used alone or with another medication called ursodiol. There's currently no available generic version of obeticholic acid. Common side effects include itchiness, fatigue, and stomach pain, but it also has a warning for liver problems.
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why choose us
Our Factory
Package
Shipping Methods
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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