Nepafenac Powder CAS 78281-72-8

Nepafenac Powder is a novel ocular non-steroidal antipyretic, analgesic and anti-inflammatory drug (NSAIDs), which is used to treat eye pain and inflammation caused by cataract surgery. Compared with traditional NSAIDs, NEPafenac's chemical structure facilitates the drug to penetrate the cornea quickly and distribute at its target site. Therefore, it helps to reduce the accumulation of drugs on the surface of the cornea, reduce the occurrence of complications on the surface of the eye, and has the advantages of strong penetration, strong targeting effect and small toxic side effects.

After the administration of Nepafenac through the eye, it can quickly cross the cornea and be converted to Fenazox (an NSAID) under the action of the eye tissue hydrolase. Fenazox plays an anti-inflammatory and analgesic role by inhibiting prostaglandin H synthetase (cyclooxygenase) and blocking prostaglandin synthesis. As is well known, prostaglandins are one of the mediators that cause intraocular inflammation, which can lead to the breakdown of the blood-aqueous barrier, vasodilation, increased vascular permeability and leukocyte chemotaxis, etc. In addition, prostaglandin can also contract the iris sphincter through non-cholinergic mechanisms, leading to the constriction of the eyes during and after ophthalmic surgery. Intranocular administration of NSAIDs can inhibit the synthesis of prostaglandin in the iris, ciliary body, and conjunctiva, thereby preventing ocular inflammation and reducing associated pain.