What is Acetylsalicylic acid?
Acetylsalicylic acid is a derivative of salicylic acid, which originated from willow bark. In ancient times, both the East and the West recorded that willow bark was used as medicine to relieve arthritis, and its active ingredient was salicylic acid, the hydrolysis product of Salicin in willow bark.
Salicylic acid has pungent sour taste, unstable chemical properties and limited clinical use. In 1853, French chemist Charles treated sodium salicylate with acetyl chloride to synthesize Acetylsalicylic Acid for the first time.
Acetylsalicylic Acid, like salicin, is hydrolyzed to salicylic acid. Acetylsalicylic acid or a willow bark is added in flower arrangement, and salicylic acid can be found in water, which can not only play an antibacterial and antiseptic role, but also prolong the life of flower arrangement.
Acetylsalicylic Acid can be rapidly decomposed in ammonium acetate or alkali metal acetate, carbonate, citrate and hydroxide solution. Aspirin is stable in dry air, but it will gradually hydrolyze into acetic acid and salicylic acid in humid environment. Acetylsalicylic Acid is rapidly hydrolyzed in alkaline solution to form a clear solution containing only salicylate and acetate.
Acetylsalicylic Acid powder is a white crystal powder with molecular formula of C9H8O4, molecular weight of 180.16, melting point of 136℃, odorless or slightly acetic acid odor, slightly soluble in water (3mg/ml), acidic in aqueous solution, soluble in fatty solvents such as ethanol, ether, chloroform, etc., and also soluble in strong alkali liquor, and decomposed.
| Product name | Acetylsalicylic acid |
| CAS | 50-78-2 |
| Molecular formula | C9H8O4 |
| Molecular weight | 180.16 |
| EINECS Number | 200-064-1 |
| Storage condition | 2-8°C |
| Melting point | 134-136 °C (lit.) |
| Solubility | Solubility in water is 10 mg/mlat 37 C. |
| Appearance | White powder |
| Boiling point | 272.96°C (rough estimate) |
| Density | 1.35 |
What is the pharmacological action of Acetylsalicylic acid powder?
Acetylsalicylic acid is a traditional antipyretic and analgesic drug, and it also has the effect of anti-platelet aggregation. Acetylsalicylic acid has antithrombotic properties in vivo, which can reduce the formation of obstructive thrombosis in peripheral arteries. Inhibit the release reaction of platelets and the release of endogenous ADP and 5-HT. Therefore, the second phase aggregation of platelets is inhibited without inhibiting the first phase aggregation. The mechanism of Acetylsalicylic acid powder is to acetylate the cyclooxygenase of platelets, thus inhibiting the formation of intracyclic peroxide and reducing the formation of TXA2. At the same time, it can acetylate platelet membrane proteins and inhibit platelet membrane enzymes, which also helps to inhibit platelet function. Because cyclooxygenase is inhibited, it affects the synthesis of PGI 2 in vascular wall; It can also inhibit the enzyme synthesized by platelet TXA2, for example, the production of TXA2 and PGI2 will be affected at high dose. It is suitable for ischemic heart disease, after percutaneous coronary intervention (PTCA) and coronary artery bypass grafting, and can prevent transient cerebral ischemia, stroke and myocardial infarction and reduce the incidence of arrhythmia.
Product Specification
| Item | Specification | Results |
| Assay | ≥99% | 99.80% |
| Appearance | White Powder | Complies |
| Loss on Drying | ≤1.0% | 0.04% |
| Ash | ≤1.0% | 0.10% |
| As | ≤2.0ppm | <2.0ppm |
| Pb | ≤2.0ppm | <2.0ppm |
| Insoluble impurity content | ≤0.05% | Complies |
| Total Plate Count | ≤1000 cfu/g | Complies |
| Yeast &. Mold | ≤100 cfu/g | Complies |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion | Conform USP Standard. | |
Where is Acetylsalicylic acid applied?
1. Acetylsalicylic acid is the raw material for preparing 4-hydroxycoumarin, an intermediate of rodenticide.
2. Acetylsalicylic acid is used to manufacture outdoor and strong light-irradiated structural parts and instrument parts, such as automobile bodies, agricultural machinery parts, electric meters and lampshades, road markings, etc.
3. It is an antipyretic and analgesic drug used for fever, pain and rheumatoid arthritis.
4. Manganese can be verified. Organic synthesis. Acetylsalicylic acid inhibits the production of prostatic cord by inhibiting cyclooxygenase, especially for COX-1 isoform. Its antithrombotic effect is due to the inhibition of COX-1, which plays a role in coagulation and platelet aggregation.
5. Acetylsalicylic acid is the earliest, most widely used and most common antipyretic and analgesic antirheumatic drug. It has many pharmacological effects, such as antipyretic, analgesic, anti-inflammatory, wind-resistant and anti-platelet aggregation, etc., with rapid and definite efficacy, easy diagnosis and treatment of overdose, and few allergic reactions.
HTML5 atlas of Acetylsalicylic acid
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Is acetylsalicylic acid the same as paracetamol?
Acetylsalicylic acid is not paracetamol, but paracetamol refers to acetaminophen, acetaminophen and acetylsalicylic acid, both of which can play an antipyretic and analgesic role, but they are not the same product.
The main component of acetylsalicylic acid is acetylsalicylic acid powder, which can improve fever, headache and neuralgia, and can also improve muscle pain, joint pain and menstrual pain. The main component of acetaminophen is acetaminophen powder, which can improve fever and headache caused by common cold and influenza, and also help relieve joint pain, neuralgia and other symptoms, so acetylsalicylic acid is not acetaminophen. Although acetylsalicylic acid and paracetamol tablets do not belong to the same product, they have the same function, and any product has side effects. In order to reduce the adverse reactions caused by drugs, it is necessary to use drugs in strict accordance with the doctor's advice.
Acetylsalicylic Acid should be prohibited in the following case：
(1) ulcer with bleeding symptoms or other active bleeding;
② Ulcer or corrosive gastritis;
③ glucose-6-phosphate dehydrogenase deficiency (occasionally causing hemolytic anemia);
④ Gout (Acetylsalicylic Acid can affect the action of other uric acid excretion drugs, and may cause uric acid retention in small doses);
⑤ Hepatic toxicity and bleeding tendency can be aggravated when liver function declines, and patients with hepatic insufficiency and cirrhosis are prone to renal adverse reactions;
⑥ Cardiac insufficiency or hypertension may cause heart failure or pulmonary edema when used in large quantities;
⑦ Renal failure may aggravate renal toxicity.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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