Mifepristone Powder CAS 84371-65-3

Mifepristone powder is a viscous yellow solid organic compound with poor stability. It can be stored for 1 year after production, and its ethanol solution can be stored for up to 3 months at -20 ℃. The chemical formula is C29H35NO2, which belongs to the anti progesterone product. It is a new type of anti fertility drug that acts at the receptor level, first developed by the French company Roussel Ulsf in the early 1980s. According to tests, this product has no progesterone, androgen, or estrogenic activity.

Is mifepristone a hormone product?

Mifepristone is not a hormone drug, but it is a new type of steroid based anti progestogen preparation that has the activity of antagonizing progestogens and anti glucocorticoids, without the activity of progestogens, estrogens, androgens, and anti estrogens. Mifepristone has the effects of preventing fertilized egg implantation, inducing menstruation, and promoting cervical maturation. Its mechanism of promoting menstruation and stopping pregnancy is mainly through competing for progesterone receptors in the endometrium (decidua), blocking the effect of progesterone.

What is the difference between mifepristone and progesterone?

Progesterone is a type of progestational hormone that can cause endometrial hyperplasia and transform the endometrium into secretory endometrium, but progesterone itself is not equivalent to contraceptive pills. On the contrary, due to its inhibitory effect on uterine contractions, it is beneficial for the growth and development of embryos and fetuses in the uterus. Therefore, it is not only not used for abortion, but is often used in clinical practice for fetal protection treatment and restoration of the uterine environment. In clinical practice, the affinity between mifepristone and progesterone receptors is five times stronger than progesterone, making it a competitive receptor for progesterone, thus achieving the effect of antagonizing progesterone. At the same time, it also has a certain binding force with glucocorticoid receptors, making it a very commonly used contraceptive and abortion product, similar to misoprostol. However, this product has some help in treating diseases such as uterine fibroids and adenomyosis.In summary, the functions of the two products are different, so they cannot be used simultaneously, otherwise it may lead to endocrine dysfunction, and in severe cases, it may cause continuous vaginal bleeding.In summary, progesterone can regulate the menstrual cycle and also has the effect of protecting the fetus. It is a hormone drug that is beneficial for the normal growth and development of the fetus. Mifepristone is an anti progestogen medication that can cause miscarriage and also has contraceptive effects when taken. So in theory, the two functions are opposite and cannot be used simultaneously, otherwise it will lead to endocrine dysfunction, and in severe cases, it may cause continuous vaginal bleeding.If you need to regulate your menstrual cycle, please use progesterone. If it is a medical abortion, you can first use mifepristone for abortion, and then use progesterone to promote the recovery of the endometrium after success. However, it should be noted that regardless of the purpose, permission from a doctor must be obtained before use.We can support the research on progesterone, mifepristone and misoprostol. If you are interested, please contact us a message by email:sales6@faithfulbio.com.

What are the other clinical applications of mifepristone tablets?

Mifepristone is a commonly used emergency contraceptive product, which is usually used for accidental contraception or contraception after sexual intercourse without any contraceptive measures. In addition, this product is also clinically used for drug abortion in early pregnancy, softening the cervix to assist in removing the ring, and treating hysteromyoma, ectopic pregnancy, endometriosis and so on.
1. Emergency contraception. Used as a remedial measure to prevent unintended pregnancy after unprotected sex or within 72 hours after contraceptive failure.

2. Drug abortion in early pregnancy. The combination of mifepristone tablets and pure misoprostol is suitable for healthy women who are pregnant within 7 weeks to terminate early pregnancy.

3. Softening the cervix to assist in removing the ring. After menopause, taking out the intrauterine device has the problem of cervical dilatation. Mifepristone can soften the cervix and increase the diameter of the cervix. And misoprostol tablets can further reduce the resistance of mechanically dilating cervix.

4. Treat uterine fibroids. It is found that the growth of hysteromyoma depends on the support of progesterone, and mifepristone replaces progesterone to bind to the receptor, which can reduce the tumor volume and relieve symptoms.

5. Treat ectopic pregnancy. Mifepristone combined with methotrexate for conservative treatment of ectopic pregnancy has been gradually applied in clinical practice. If it is tubal ectopic pregnancy, mifepristone can protect the fallopian tube while terminating pregnancy, which can reduce the damage of fallopian tube tissue and maintain the integrity of fallopian tube.

6. Treatment of endometriosis. Many doctors advocate that long-term use of low-dose mifepristone can obviously reduce the volume of ectopic focus, and preoperative administration is beneficial to surgery, reducing intraoperative bleeding and resection of ectopic focus. In addition, the addition of mifepristone after operation can significantly reduce the recurrence rate after operation, thus reducing the chance of reoperation.

Is mifepristone 100% safe?

Mifepristone powder can achieve contraceptive effect by inhibiting ovulation, preventing sperm from combining with eggs and changing endometrium. The best time to use this product is as soon as possible after sex, preferably within 72 hours after sex, but not more than 120 hours at the latest. However, the risk of pregnancy can not always be completely avoided after using mifepristone, because its effect is related to the taking time and individual differences. According to clinical trials, after using mifepristone, there is about 85% to 95% possibility of successful contraception.
At the same time, it should be noted that emergency contraceptives can only be used as emergency contraception measures under special circumstances, not as routine contraception measures, nor can they be used in large quantities for a long time. Because this product may include nausea, vomiting, breast pain, headache, abdominal pain, dizziness, fatigue and irregular menstruation and so on. These side effects usually disappear on their own within a few days without further treatment. However, if it is used for a long time, it will lead to the accumulation of toxic and side effects, which will do harm to the body and even lead to other serious side effects, such as uterine spasm.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,We can support the research on progesterone, mifepristone,Methotrexate and misoprostol. If you are interested, please contact us

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