Naproxen Sodium powder is a white or off white crystalline powder, odorless, and slightly hygroscopic; Soluble in organic solvents such as ethanol, chloroform, acetone, etc; There is a positive correlation between water solubility and pH value, with higher pH values indicating greater solubility in water. RS-3650 is a non selective cyclooxygenase (COX) inhibitor with IC50 values of 8.7 μ M and 5.2 μ M, respectively, when acting on COX-1 and COX-2.
| Items | Standard | Test Result |
| Appearance | White or almost white crystalline powder | White crystalline powder |
| Identification | ||
| A. Infrared absorption | The infrared absorption spectrum is concordant with the reference spectrum | Conform |
| B. Ultraviolet Absorption | Absorptivities at 272nm, calculated on the dried base, do not differ by more than 3% | 1% |
| Specific rotation | -17.0°～-15.3° | -16.8° |
| Loss on drying | ≤1.0% | 0.2% |
| Heavy metals | ≤0.002% | ＜0.002% |
| Free Naproxen | ≤1.0% | 0.1% |
| Related substances(HPLC) | ||
| Impurity D(in-house) | ≤0.10% | ＜0.01% |
| Impurity E(in-house, impurity C in EP) | ≤0.10% | ＜0.01% |
| Any other impurity | ≤0.10% | ＜0.01% |
| Total impurities | ≤0.5% | ＜0.01% |
| Residual solvents | ||
| Toluene | ≤50ppm | ＜1ppm |
| Methanol | ≤50ppm | ＜4ppm |
| Assay(on dry basis) | 98.5%～101.5% | 100.4% |
| Conclusion | The results conform with USP38. |
What is a Nonsteroidal Antiinflammatory Drugs?
Non steroidal anti-inflammatory drugs can inhibit the activity of cyclooxygenase, reduce the synthesis of prostaglandins, alleviate inflammatory reactions, and also inhibit the activity of phosphodiesterase to increase intracellular cAMP concentration, stabilize lysosomal membranes, reduce lysosomal release, and inhibit inflammatory reactions. This mechanism of action is fundamentally different from the steroid containing anti-inflammatory drug glucocorticoids.
NSAIDs mainly include aspirin, ibuprofen, indomethacin, diclofenac, naproxen, acetaminophen and rofecoxib. According to their different chemical structures, NSAIDs can be divided into formic acid, acetic acid, propionic acid, xicam, coxib, pyrazolone and other types, and can be divided into non-selective COX inhibitors and specific COX-2 inhibitors according to their different mechanisms of action.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price. In terms of analgesic products, we can provide not only diclofenac sodium and diclofenac potassium, but also offer products such as aspirin, ibuprofen, and acetaminophen(Paracetamol). If you are interested, please leave us a message as soon as possible.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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