The appearance of acetaminophen powder is crystal, and prism crystals can be obtained if it is purified from ethanol. Melting point 168-172℃, odorless, slightly bitter, and relative density 1.293(21/4℃). Soluble in ethanol and acetone, insoluble in petroleum ether and benzene. The solubility in water is positively related to the water temperature, but it is insoluble in cold water, and the pH value of saturated aqueous solution is 5.5-6.5. It was first synthesized by Morse in 1878 and first used in clinic by VonMering in 1893. It became an over-the-counter drug in the United States in 1955, and it was produced in China in the late 1950s. Storage below 45℃ can stabilize the structure and properties of the product, but if it is exposed to humid air, it will be hydrolyzed into p-aminophenol, and then further oxidized, and the color will gradually turn pink, brown and finally black, so it is suitable to store it in a cold, dry and closed place.
Product Data
| Contents | Specification | Results |
| Characters | White, odorless, crystalline powder, having a slightly bitter taste. | Conforms |
| Solubility | Freely soluble in alcohol; soluble in boiling water and in 1 N sodium hydroxide. | Conforms |
| Identification | A：IR absorption | Conforms |
| B ：The retention time of the major peak of the Sample solution corresponds to that of the standard solution, as obtained in the assay. | Conforms | |
| Loss on drying | ≤0.5% | 0.06% |
| Residue on ignition | ≤0. 1% | 0.04% |
| Free p-aminophenol | ≤0.005% | BelowLOD |
| Related substances | Impurity B ≤0.05% | 0.019% |
| Impurity C ≤0.05% | BelowLOD | |
| Impurity D ≤0.05% | BelowLOD | |
| Impurity J ≤0.001% | BelowLOD | |
| Individual unspecified impurity ≤0.05% | 0.002% | |
| Total of impurities ≤0.1% | 0.032% | |
| Residual solvents | Residual content of acetic acid is limited by the test of loss on drying.≤0.5% | 0.06% |
| Assay(anhydrous basis) | 98.0%- 101.0% | 99.8% |
| Conclusion： | It complies with the requirements of the USP43 |
Pure acetaminophen is a metabolic product of phenacetin in the body. Its inhibitory effect on central nervous system prostaglandin synthesis is similar to aspirin, but its inhibitory effect on peripheral prostaglandin synthesis is weak. Therefore, it has strong antipyretic and analgesic effects, weak anti rheumatic effects, and no effect on platelet coagulation mechanism.Our company highly values the market situation and can provide you with high-quality and low-priced acetaminophen. At the same time, I can also provide raw materials for phenacetin, Prostaglandin E2, and Acetylsalicylic acid (aspirin). If you are interested, please contact us via email:sales6@faithfulbio.com
Can pregnant women use acetaminophen?
Acetaminophen powder belongs to non steroidal anti-inflammatory drugs, which are widely used to treat pain and fever. Currently, there is no conclusive evidence showing adverse effects on pregnant women. However, due to the fact that the main components of this product can pass through the placental barrier, there are also concerns about their impact on the fetus. Therefore, in principle, pregnant women should avoid using acetaminophen tablets.
but, it should be noted that high fever in pregnant women not only endangers their own safety, but also increases the risk of deformities, miscarriage, fetal central nervous system underdevelopment, and congenital cardiovascular diseases. Therefore, in cases where physical cooling is ineffective, this product can be used for fever reduction treatment according to the doctor's advice. Moreover, this product also has a good relieving effect on pregnant migraine.
In summary, whether pregnant women can use acetaminophen depends on their actual situation. Based on years of clinical data, we have summarized the following situations:
1. If a pregnant woman has a cold (especially during the high incidence period of influenza) and her armpit temperature exceeds 38.5 ℃, or accompanied by obvious pain symptoms, the doctor can recommend that the pregnant woman take acetaminophen tablets for treatment after weighing the pros and cons. However, the use interval should be around 4-6 hours, and this product should not be used more than 4 times within 24 hours.
2. when the body has abnormal conditions, such as abdominal pain, abnormal vaginal bleeding, etc., you should seek medical treatment in time. Acetaminophen and other products should not be used blindly to relieve pain, so as not to cause adverse consequences.
3. If the armpit temperature of pregnant women does not exceed 38.5 ℃ or the degree of body pain is relatively mild, it is not recommended to use this product or other similar products, because pregnant women have high sensitivity and relatively weak resistance after pregnancy, and are easily affected by adverse factors. Therefore, easy use of drugs can easily affect the normal development of the fetus.
4. Pregnant women should maintain sufficient water intake during the use of acetaminophen to promote drug metabolism and excretion. If conditions permit, physical cooling can be carried out while fully replenishing water.
What are the pharmacological effects of this product?
The international non proprietary drug name of this product is Paracetamol. The antipyretic and analgesic effects are similar to those of phenacetin. However, due to many countries restricting or prohibiting the use of phenacetin, the application of this product has increased.
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| Acetaminophen 103-90-2 | Phenacetin 62-44-2 | Prostaglandin E2 363-24-6 | D-Glucuronic acid 6556-12-3 |
Clinical trials have found that this product selectively inhibits the synthesis of prostaglandins in the hypothalamic thermoregulatory center by inhibiting cyclooxygenase, leading to peripheral vasodilation and body sweating, thereby achieving antipyretic effects. At the same time, this product controls the synthesis and release of prostaglandins, which is very effective in increasing the body's pain threshold and thereby providing pain relief. Therefore, this product belongs to peripheral analgesics, with weaker effects than aspirin, and is only effective for mild to moderate pain. However, it should be noted that this product has no significant anti-inflammatory effect. After use, this product can be quickly and completely absorbed, with a peak time of 0.5-2 hours. The plasma protein binding rate is 25% to 50%. This product is evenly distributed in the body, with 90% to 95% metabolized in the liver and mainly excreted from the kidneys in the form of binding with glucuronic acid. Within 24 hours, about 3% is excreted in its original form with urine.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price.If you are interested in purchasing Acetaminophen, Phenacetin, Prostaglandin E2, and D-Glucuronic acid, please let us know
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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