Lopinavir Powder CAS 192725-17-0

Lopinavir is a new generation HIV protease inhibitor designed and improved by Abbott Laboratories based on ritonavir. Antiretroviral drugs. Used for the treatment of HIV-1 infection in adult and pediatric patients over 6 months old. Pure Lopinavir powder is white to beige, and its solubility in DMSO is 20mg/mL. It can not only be used for AIDS virus protease inhibition, but also be used in biochemical experiments, synthesis experiments and other experiments.

What is the association between lopinavir and ritonavir?

Both lopinavir and ritonavir are viral reverse transcriptional inhibitors and protease inhibitor anti AIDS products. They inhibit viral replication by blocking the division of Gag Pol poly protein to produce immature and non infectious viral particles.
We know that P-gp and MRP2, which are highly expressed on the luminal surface of intestinal epithelial cells, mediate efflux pumping, and the extensive metabolic activity of CYP3A4 enzyme in the liver,
However, the low water solubility of lopinavir itself (40mg/mL) and poor bioavailability when taken orally make it difficult to fully exploit the functions of this product.
If the strategy to improve the bioavailability of lopinavir focuses on inhibiting the normal physiological function of efflux pumps, it may have serious side effects on the body.
Although ritonavir is a protease inhibitor and has a strong inhibitory effect on CYP450 enzyme (CYP3A4 is its isoenzyme), the side effects of this product are quite obvious and cannot be used all at once.
Clinical trial data shows that combining the two, with lopinavir as the main drug, and competitive binding of CYP3A4 with low-dose ritonavir and lopinavir.
In this way, not only can the combination of lopinavir and viral protease be utilized to produce immature and non infectious viral particles; It can also exert the inhibitory effect of ritonavir on the metabolism of lopinavir in the liver, thereby increasing the blood concentration of lopinavir, improving the overall effect of the product, and fundamentally reducing the side effects of both products.
Abbott Laboratories has developed a combination of lopinavir and ritonavir, consisting of one unit dose of lopinavir and one quarter dose of ritonavir. This preparation was approved by the FDA for marketing in the United States in 2000 ,and in China in 2007.

Our company can provide low-priced Lopinavir and Ritonavir. If you have purchasing plans, please contact us via email:sales6@faithfulbio.com

Which drugs should not be taken simultaneously with Lopinavir and Ritonavir tablets?

Lopinavir and ritonavir tablets are suitable for combination therapy with other antiretroviral drugs to treat HIV infection, but Lopinavir and ritonavir cannot be used simultaneously with the following products:

1. Products that rely on CYP3A for clearance, such as carbamazepine, 5,5-Diphenylhydantoin, rifampicin, and nevirapine, induce the metabolism of lopinavir and reduce its blood drug concentration.

2.The combination of ritonavir and Dideoxyinosine can lead to the inactivation of both. Therefore, the two medications should be taken separately with a minimum interval of 2.5 hours.

3. Efavirenz can promote the metabolism of lopinavir and ritonavir tablets and reduce the blood drug concentration of this product. When used together, the dosage of this product should be increased.

4. The combination of allicin or St. John's wort can reduce the blood concentration of this product. When used together, the dosage of this product should be increased.

5.Lopinavir can reduce the blood concentration of Atovaquone, and when used in combination, it may be necessary to increase the dose of Atovaquone.

6.It is not recommended to use statins (such as atorvastatin and Rosuvastatin calcium) in combination, but if combination is necessary, the dosage should be adjusted and safety monitoring should be conducted.

7.Caution should be exercised when using products that can induce QT interval prolongation, such as quinidine, erythromycin, and clarithromycin. Because this product will increase the blood drug concentration of co administered drugs and further lead to an increase in product related cardiac adverse events.

8.Caution should be exercised when using drugs that can cause PR interval prolongation, such as verapamil or atazanavir, as 2nd or 3rd degree atrioventricular block may occur.

If you need to use other medications (including prescription or over-the-counter drugs, natural products, vitamins) during the use of this product, you must first obtain permission from a doctor.

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