Erdafitinib API CAS 1346242-81-6

Erdafitinib Introduction

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Erdafitinib API is an oral targeted product, specifically designed for treating patients with advanced bladder cancer who carry specific genetic mutations. Its appearance is in the form of Yellow powder, with CAS number: 1346242-81-6; Molecular formula: C25H30N6O2; Molecular weight: 446.54, EINECS number: 610-261-8.  

What is the mechanism of action of erdafitinib?

 Erdafitinib is a broad-spectrum fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitory molecule. This substance can reversibly compete for binding to the ATP binding sites of the four receptor subtypes (FGFR1, FGFR2, FGFR3, and FGFR4), blocking the phosphorylation process of the FGFR receptors themselves, and simultaneously inhibiting the activation of downstream core signaling pathways such as RAS-MAPK, PI3K-AKT, and STAT3.
When FGFR undergoes mutations or gene fusions, it causes continuous abnormal activation of the above pathways, promoting the continuous proliferation, survival of abnormal cells, and inducing the formation of new blood vessels. By targeting the inhibitory pathway, the Erdafitinib API can effectively block the proliferation process of abnormal cells carrying FGFR mutations, induce programmed cell apoptosis, and demonstrate significant proliferation inhibition effects in related tumor cell model experiments.

What is the use of erdafitinib?

The core of Erdafitinib API serves as a target pathway research substrate, corresponding to the core active raw material of the commercialized research formulation Balversa. This substance currently has mature application scenarios in research, targeting advanced and metastatic urothelial-related cell models carrying FGFR3 gene mutations; the test system needs to undergo at least one round of systemic pathway intervention (including PD-1/PD-L1 related regulatory substrates) before showing progression, and prior to conducting the trial, genetic typing detection must be carried out to confirm the existence of the target mutation site.
Considering that FGFR gene mutations are widely present in various abnormal cell models, currently ERDAFITINIB is conducting multi-directional in vitro and in vivo experiments, covering FGFR2 gene fusion bile duct cell models, non-small lung cells carrying FGFR mutations, esophagus, liver, and pediatric solid abnormal cells, etc.; at the same time, it is also evaluating and combining with immune regulatory substrates to assess the feasibility of combined intervention in the initial model.

MF of ERDAFITINIB

CAS	1346242-81-6
Molecular formula	C25H30N6O2
Molecular weight	446.54
EINECS	610-261-8
Density	1.20±0.1 g/cm3
Melting point	136-140°C
Boiling point	662.3±55.0 °C

Specification

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FAQ: 

Q1:What kind of inspection must be conducted before use?
It is necessary to confirm through companion diagnostic tests that there are specific FGFR gene mutations in the tumor tissue; otherwise, this product will be ineffective and should not be used.
Q2:What is the most critical side effect to be vigilant about when using ERDAFITINIB?
Ocular toxicity (central serous retinopathy) may cause blurred or reduced vision. An ophthalmological examination should be conducted monthly within the first 4 months of use, and then every 3 months thereafter.
Q3:Regarding the increase in blood phosphorus, what should be noted?

Hyperphosphatemia is a common side effect (with an extremely high incidence rate) caused by the action of erdafitinib. Although most cases can be controlled, regular blood tests are required to monitor the blood phosphorus level. In severe cases, the dosage should be reduced or the medication should be stopped as per the doctor's advice.

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