Erdafitinib Introduction
Erdafitinib API is an oral, highly potent, broad-spectrum fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.CAS:1346242-81-6; As the core active ingredient of the marketed targeted compound Balversa, this compound is widely used in global basic and clinical research on tumor mechanisms.Molecular formula: C25H30N6O2; It can precisely act on cell models with mutations or fusions in FGFR1/2/3/4, cutting off the activation pathways of abnormal signal cascades, thereby achieving significant anti-tumor proliferation effects.
MF of ERDAFITINIB
| Product name | Erdafitinib |
| CAS | 1346242-81-6 |
| Molecular formula | C25H30N6O2 |
| Molecular weight | 446.54 |
| EINECS | 610-261-8 |
| Density | 1.20±0.1 g/cm3 |
| Melting point | 136-140°C |
| Boiling point | 662.3±55.0 °C |
What is the mechanism of action of erdafitinib?
Erdafitinib API can bind reversibly and competitively to the ATP active sites of FGFR1, FGFR2, FGFR3 and FGFR4. This is how it delivers targeted anti-tumor effects.
This binding stops FGFR receptors from self-phosphorylation, and blocks abnormal activation of downstream signaling pathways such as RAS-MAPK, PI3K-AKT and STAT3, which are closely linked to tumor growth.
FGFR gene mutations and fusions are key drivers for the growth of many malignant tumors.
As an API, Erdafitinib suppresses these abnormal pathways. It can slow proliferation and angiogenesis of tumor cells with FGFR mutations, trigger programmed cell death, and inhibit tumor growth in both in vitro and in vivo tests.
How To Cooperate With faithful?
Xi'an Faithful BioTech Co., Ltd.
We are a reliable raw material supplier from Xi'an, China. We have nearly ten years of export experience and are capable of handling both sample prototyping and large-scale orders.
Our team has very rich and mature experience in this industry. From product quality to goods transportation and then to customer service, we can offer you a perfect shopping experience.
If you have any questions regarding Erdafitinib or other product quantities, prices, shipping methods, payment methods, etc., please click the link below and immediately navigate to our customer contact service for consultation!
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What is the purpose of erdafitinib?
Erdafitinib API serves as a core substrate for targeted pathway studies, and is the key active material of Balversa. You can get fully characterized material for your research when purchasing from our factory
It is widely used in research on advanced and metastatic urothelial cell models with FGFR3 mutations. A genetic test to confirm target mutation sites is required before trials. Faithful supplies full COA and supporting documents for your experimental verification.
FGFR mutations exist across various tumor cell models. Erdafitinib is used in multiple in vitro and in vivo tests, including FGFR2 fusion bile duct, FGFR-mutated non-small cell lung, esophageal, liver and pediatric solid tumor models. Faithful offers sample and bulk orders to fit your repeated testing.
Scientists also test Erdafitinib together with immune regulatory substrates to explore combined pathway intervention. Faithful can provide steady, consistent batches of Erdafitinib to support your combined research projects.
Specification
| Items | Specification | Results |
| Appearance | Yellow solid | Conforms |
| NMR | Conforms to structure | Conforms |
| Infrared Spectrum | Conforms to structure | Conforms |
| Assay | ≥98.5% | 99.40% |
| Conclusion | Conform with enterprise specification | |
Click email：sales6@faithfulbio.com Or WhatsApp：+86 17782780648
A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Erdafitinib API etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:What kind of inspection must be conducted before use?
It is necessary to confirm through companion diagnostic tests that there are specific FGFR gene mutations in the tumor tissue; otherwise, this product will be ineffective and should not be used.
Q2:What is the most critical side effect to be vigilant about when using ERDAFITINIB?
Ocular toxicity (central serous retinopathy) may cause blurred or reduced vision. An ophthalmological examination should be conducted monthly within the first 4 months of use, and then every 3 months thereafter.
Q3:Regarding the increase in blood phosphorus, what should be noted?
Hyperphosphatemia is a common side effect (with an extremely high incidence rate) caused by the action of erdafitinib. Although most cases can be controlled, regular blood tests are required to monitor the blood phosphorus level. In severe cases, the dosage should be reduced or the medication should be stopped as per the doctor's advice.
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