Characteristics of fenofibrate：
Fenofibrate, also known as sodium crystal or sodium metal, is a chemical element with metallic properties. The following are the main characteristics of fenofibrate:
1. Appearance: Fenofibrate is a silvery metallic solid with good luster.
2. Density: The density of fenofibrate is relatively low, about 0.97 g/cm3, which is lighter than water.
4. Conductivity: Fenofibrate is a good conductor because it has freely moving electrons and can flow freely in metals.
5. Reactivity: Fenofibrate is a highly reactive metal, which will react with oxygen to produce sodium oxide and with water to produce hydrogen and sodium hydroxide.
It is more fluid in liquid state than in solid state.
In laboratory or industrial production, safety measures are usually taken to handle and store fenofibrate.
| Product name | Fenofibrate |
| CAS | 49562-28-9 |
| Molecular formula | C20H21ClO4 |
| Molecular weight | 360.83 |
| EINECS Number | 256-376-3 |
| Water soluble | 0.8mg/L(25 ºC) |
| Melting point | 80-810ºC |
| Solubility | Almost insoluble in water, extremely soluble in dichloromethane and slightly soluble in ethanol (96%). |
| Appearance | Off-white powder |
| Boiling point | 469.8±35.0 °C(Predicted) |
| Density | 1.177±0.06 g/cm3(Predicted) |
What is Fenofibrate?
Fenofibrate is mainly used for hypercholesterolemia, hypertriglyceridemia and mixed hyperlipidemia, especially for hyperuricemia. It is also used to reduce high-density lipoprotein-cholesterol, increase low-density lipoprotein-cholesterol level, and increase triglyceride decomposition to play a role. Because it can promote the excretion of uric acid, it can reduce the level of blood uric acid.
Identification of Fenofibrate
Fenofibrate powder identification is a commonly used chemical test method to detect the presence of nitrite. Nitrite is a kind of compound containing nitroso (NO2), which can cause many health problems. Its accurate and reliable detection method is very important.
The identification of fenofibrate uses nitrite to react with naphthylamine under acidic conditions to produce blue Diazonium. This reaction can be used to identify the presence of nitrite.
The identification steps of fenofibrate are as follows:
1. Take a test tube and add the sample to be tested.
2. Add a few drops of acidic sodium bromate solution, which will oxidize nitrite to nitrous acid.
3. Add a drop of sulfuric acid solution containing naphthylamine, which will react with nitrous acid to produce blue azo naphthalene salt. If blue is produced, it means that nitrite exists in the sample.
The identification results need to be carried out under weak acidic conditions, and too strong acidic environment or too high temperature will interfere with the reaction results.
Product Specification
| Item | Specification | Results |
| Physical Analysis | ||
| Description | White Powder | Complies |
| Assay | ≥99% | 99.6% |
| Mesh Size | 100 % pass 80 mesh | Complies |
| Ash | ≤ 5.0% | 2.85% |
| Loss on Drying | ≤ 5.0% | 2.65% |
| Chemical Analysis | ||
| Heavy Metal | ≤ 10.0 mg/kg | Complies |
| Pb | ≤ 2.0 mg/kg | Complies |
| As | ≤ 1.0 mg/kg | Complies |
| Hg | ≤ 0.1mg/kg | Complies |
| Microbiological Analysis | ||
| Residue of Pesticide | Negative | Negative |
| Total Plate Count | ≤ 1000cfu/g | Complies |
| Yeast&Mold | ≤ 100cfu/g | Complies |
| E.coil | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion：Conform with enterprise specification . | ||
What is the pharmacological action of Fenofibrate?
What is the lipid-lowering mechanism of Fenofibrate?
The lipid-lowering mechanism of fenofibrate may be through interaction with peroxisome proliferator-activated receptor (PRARα), which regulates the gene expression of enzymes involved in fatty acid oxidation. Fenofibrate can increase lipoprotein lipase levels, thereby enhancing the clearance of high triglyceride lipoproteins.
How does fenofibrate work?
Fenofibrate powder can reduce blood low density lipoprotein, cholesterol and triacylglycerol, and increase blood high density lipoprotein. The lipid-regulating effect of this product is mainly through activating peroxisome proliferator-activated receptor (PPAR)α, so that the small and dense part of low-density lipoprotein is reduced and the large and sparse part is relatively increased. Inhibit the production of very low density lipoprotein and increase the decomposition of triacylglycerol; It also increases the production of apolipoprotein A-I and A-II, thus increasing high density lipoprotein. The product also has the effect of reducing blood uric acid in patients with hyperuricemia.
Why use fenofibrate?
Fenofibrate powder is used along with a low-fat diet, exercise, and sometimes other products to reduce the amount of fatty substances (such as cholesterol and triglycerides) in the blood and to increase the amount of HDL (high-density lipoprotein; a fatty substance that may reduce the risk of heart disease) in the blood. The buildup of cholesterol and fat in the walls of arteries (a process called atherosclerosis) reduces blood flow and therefore the oxygen supply to the heart, brain, and other parts of the body. This increases the risk of heart disease, angina (chest pain), stroke, and heart attack. Although fenofibrate can reduce the level of fatty substances in the blood, it has not been shown to reduce the risk of heart attack or stroke. Fenofibrate belongs to a class of products called antilipid drugs. It works by speeding up the natural process of removing cholesterol from the body.
HTML5 atlas of fenofibrate
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Precautions
You should not take fenofibrate if you have liver disease, gallbladder disease, severe kidney disease or are breastfeeding your baby.
Fenofibrate can lead to the decomposition of muscle tissue, which leads to renal failure. If you have unexplained muscle pain, tenderness or weakness, especially with fever, abnormal fatigue or dark urine, please seek medical attention immediately.
How and where to buy fenofibrate wholesale?
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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