Entecavir Powder CAS 142217-69-4
Product Name:Entecavir
Synonym:entecavir;Baraclude;Aids098045;Aids-098045;Etv;EntikaweiPian
CAS NO.:142217-69-4
EINECS NO.:604-279-5
Molecular Formula:C12H15N5O3
Purity & Grade: 99%; Medicine grade
Character:White powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 10g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description

Entecavir Powder is a new generation of guanine nucleoside analogues for the treatment of hepatitis B virus infection. It is mainly used for the treatment of chronic hepatitis B in adults with active viral replication, continuous increase of serum aminotransferase, or active liver histology. It is currently the fastest and strongest nucleoside analogues with the lowest rate of mutation. Entecavir is a purine nucleoside derivative, has an inhibitory effect on DNA synthesis, and its anti-herpesvirus activity is 160 times stronger than that of adenosine arabine. It is clinically used for simple herpes virus encephalitis, herpes virus keratitis and external genital infection, AIDS varicella zoster virus infection and cytomegalovirus infection, chronic hepatitis B and so on.
Common side effects include headache, nausea, high blood sugar, and decreased kidney function. Severe side effects include enlargement of the liver, high blood lactate levels, and liver inflammation if the medication is stopped. While there appears to be no harm from use during pregnancy, this use has not been well studied. Entecavir is in the nucleoside reverse transcriptase inhibitors (NRTIs) family of medications. It prevents the hepatitis B virus from multiplying by blocking reverse transcriptase.

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COA
| Items | Standards | Results | |
| Appearance | White or off-white solid powder | White solid powder | |
| Identification | By IR | Complies | |
| By HPLC | Complies | ||
| Specific Rotation | +24.0°~+28.0°(DMF:MeOH=1:1 c=1%) | +9.5° | |
| pH | 5.5~7.5 | 6.8 | |
| Water Content | 5.6%~7.2% | 6.10% | |
| Heavy Metal | ≤ 20ppm | Complies | |
| Residue on Ignition | ≤ 0.10% | 0.04% | |
| Enantiomer | ≤ 0.20% | ND | |
| Residual Solvents | M'ethanol: ≤3000ppm | ND | |
| D'ichloromethane: ≤600ppm | ND | ||
| T'etrahydrofuran: ≤720ppm | ND | ||
| T'oluene: ≤890ppm | ND | ||
| H'exane: ≤290ppm | ND | ||
| DMF: ≤880ppm | ND | ||
| Related Substances | Any single impurity: ≤0.10% | 0.05% | |
| Total Impurities: ≤0.30% | 0.07% | ||
| Assay | 98.0%~102.0% | 99.90% | |
| (HPLC basis on drying) | |||
| Conclusion | Conform with enterprise specification . | ||
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What is the difference between entecavir and tenofovir?
Conclusion: Tenofovir presented a significantly lower incidence of cirrhosis-related complications than Entecavir Powder in patients with hepatitis B virus-related cirrhosis. However, no statistically significant difference in death and liver transplantation was seen in treatment-experienced patients.
How effective is entecavir?
In addition, one-year treatment is associated with a 5 to 7 log(10) reduction in mean HBV DNA levels and corresponding improvement in liver histology. The rate of virologic resistance is around 1 percent with up to five years of follow-up.
Is entecavir lifelong?
Treatment of chronic hepatitis B with entecavir or tenofovir leads to viral suppression in almost all patients. However, prolonged or lifelong treatment is necessary.
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Package

Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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