Bortezomib powder, a drug for the treatment of malignant tumors in the hematopoietic system, is white or nearly white crystalline powder, which is soluble in dimethyl sulfoxide and ethanol, but insoluble in water solution. Melting point: 122-124°C, molecular formula: C19H25BN4O4, molecular weight: 384.23700, density: 1.214.
Bortezomib can be combined with melphalan and prednisone for the treatment of previously untreated patients with multiple myeloma who are not suitable for high-dose chemotherapy and bone marrow suppression; It can also be used for the treatment of patients with recurrent or refractory mantle cell lymphoma, who had received at least one treatment before using Bortezomib.
What is Bortezomib?
Bortezomib powder is a new anti-tumor drug developed by the American Millennium Pharmaceutical Company. It is a 26S proteasome inhibitor, which blocks the degradation of various proteins which regulate apoptosis and signal transduction in cells, and leads to the death of tumor cells.
Bortezomib is an anticancer drug and the first therapeutic proteasome inhibitor for humans. A proteasome is a cell complex that decomposes protein. In some cancers, protein, which usually kills cancer cells, breaks down too quickly. Bortezomib interrupted this process and let these proteins kill cancer cells. It is approved for the treatment of recurrent multiple myeloma and mantle cell lymphoma in the United States and Europe. In multiple myeloma, the complete clinical response has been achieved in patients with other refractory or rapidly progressing diseases.
Bortezomib is the first synthetic proteasome inhibitor in the world, which can delay, stop and treat the deterioration of multiple myeloma and mantle cell lymphoma. It is a new anticancer drug for targeted therapy. The inhibition of proteasomes is reversible, so controllable and predictable medication safety is its greatest advantage.
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Real shot pictures of Bortezomib raw powder | Bortezomib structure diagram |
How does Bortezomib work?
Bortezomib is a reversible inhibitor of the chymotrypsin-like activity of 26S proteasome in mammalian cells. 26S proteasome is a large protein complex, which can degrade ubiquitinated protein. Ubiquitin proteasome channel plays an important role in regulating the concentration of specific proteins in cells to maintain the stability of the intracellular environment. Protein hydrolysis will affect the multi-level signal series in cells, and this damage to the normal intracellular environment will lead to cell death. The inhibition of the 26S proteasome can prevent the hydrolysis of specific proteins. In vitro experiments have proved that bortezomib is cytotoxic to many types of cancer cells. Pre-clinical tumor model in vivo tests has proved that bortezomib can delay the growth of tumors including multiple myeloma.
What should I pay attention to when using Bortezomib?
It should be used under the supervision of a doctor with experience in the use of antineoplastic drugs, and the whole blood cell count (CBC) should be monitored frequently during its use of it. It is an anti-tumor drug, so it should be carefully prepared and operated on with gloves to prevent skin contact.
The safety characteristics of Bortezomib monotherapy are similar to those observed in the combination of melphalan and prednisone.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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